ENSMUSG00000037940


Mus musculus

Features
Gene ID: ENSMUSG00000037940
  
Biological name :Inpp4b
  
Synonyms : Inpp4b / Q6P1Y8 / Type II inositol 3,4-bisphosphate 4-phosphatase
  
Possible biological names infered from orthology : inositol polyphosphate-4-phosphatase type II B / O15327
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C2
Gene start: 81342556
Gene end: 82127914
  
Corresponding Affymetrix probe sets: 10573082 (MoGene1.0st)   1438577_at (Mouse Genome 430 2.0 Array)   1441416_at (Mouse Genome 430 2.0 Array)   1457359_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132156
Ensembl peptide - ENSMUSP00000131947
Ensembl peptide - ENSMUSP00000148972
Ensembl peptide - ENSMUSP00000150541
Ensembl peptide - ENSMUSP00000150520
Ensembl peptide - ENSMUSP00000044466
Ensembl peptide - ENSMUSP00000105477
Ensembl peptide - ENSMUSP00000105478
Ensembl peptide - ENSMUSP00000130104
Ensembl peptide - ENSMUSP00000131324
NCBI entrez gene - 234515     See in Manteia.
MGI - MGI:2158925
RefSeq - XM_017312729
RefSeq - XM_006530855
RefSeq - XM_006530856
RefSeq - XM_006530857
RefSeq - XM_006530858
RefSeq - XM_006530861
RefSeq - XM_006530862
RefSeq - XM_006530863
RefSeq - XM_011248351
RefSeq - XM_011248352
RefSeq - XM_017312726
RefSeq - XM_017312728
RefSeq - NM_001024617
RefSeq - NM_001297591
RefSeq - NM_001297593
RefSeq - NM_001297596
RefSeq - XM_006530854
RefSeq Peptide - NP_001284525
RefSeq Peptide - NP_001019788
RefSeq Peptide - NP_001284520
RefSeq Peptide - NP_001284522
swissprot - E9Q7X1
swissprot - Q6P1Y8
swissprot - E9PVM1
swissprot - Q3URI3
swissprot - E9Q2C4
swissprot - F8WJC1
swissprot - E9PVM3
Ensembl - ENSMUSG00000037940
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 inpp4bENSDARG00000075201Danio rerio
 INPP4BENSGALG00000009880Gallus gallus
 INPP4BENSG00000109452Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Inpp4a / type I inositol 3,4-bisphosphate 4-phosphatase isoform 5 / Q96PE3* / inositol polyphosphate-4-phosphatase type I A*ENSMUSG0000002611341


Protein motifs (from Interpro)
Interpro ID Name
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006874 cellular calcium ion homeostasis IGI
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 biological_processGO:0046822 regulation of nucleocytoplasmic transport IMP
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0046855 inositol phosphate dephosphorylation ISO
 biological_processGO:0046856 phosphatidylinositol dephosphorylation ISO
 biological_processGO:0051896 regulation of protein kinase B signaling IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008289 lipid binding IDA
 molecular_functionGO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034593 phosphatidylinositol bisphosphate phosphatase activity IDA
 molecular_functionGO:0034594 phosphatidylinositol trisphosphate phosphatase activity IDA
 molecular_functionGO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of IP2, IP, and Ins in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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