Manteia - Molecule gene

ENSMUSG00000026272

Mus musculus

Features

Gene ID:	ENSMUSG00000026272

Biological name :	Agxt

Synonyms :	Agxt / O35423 / Serine--pyruvate aminotransferase, mitochondrial

Possible biological names infered from orthology :	alanine-glyoxylate aminotransferase / P21549

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	D
Gene start:	93135240
Gene end:	93145421

Corresponding Affymetrix probe sets:	10348702 (MoGene1.0st) 1418833_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000027491 NCBI entrez gene - 11611 See in Manteia. MGI - MGI:1329033 RefSeq - NM_016702 RefSeq - NM_001276710 RefSeq Peptide - NP_001263639 RefSeq Peptide - NP_057911 swissprot - O35423 Ensembl - ENSMUSG00000026272

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
agxta	ENSDARG00000052099	Danio rerio
agxtb	ENSDARG00000018478	Danio rerio
AGXT	ENSGALG00000020943	Gallus gallus
AGXT	ENSG00000172482	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000192	Aminotransferase class V domain
IPR015421	Pyridoxal phosphate-dependent transferase, major domain
IPR015422	Pyridoxal phosphate-dependent transferase domain 1
IPR015424	Pyridoxal phosphate-dependent transferase
IPR020578	Aminotransferase class-V, pyridoxal-phosphate binding site
IPR024169	Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007219	Notch signaling pathway	IDA
biological_process	GO:0009436	glyoxylate catabolic process	IEA
biological_process	GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	IEA
biological_process	GO:0019448	L-cysteine catabolic process	IEA
biological_process	GO:0042853	L-alanine catabolic process	IEA
biological_process	GO:0042866	pyruvate biosynthetic process	IEA
biological_process	GO:0046487	glyoxylate metabolic process	IEA
biological_process	GO:0046724	oxalic acid secretion	IMP
biological_process	GO:0051384	response to glucocorticoid	IEA
biological_process	GO:0051591	response to cAMP	IEA
cellular_component	GO:0005739	mitochondrion	TAS
cellular_component	GO:0005759	mitochondrial matrix	IEA
cellular_component	GO:0005777	peroxisome	TAS
cellular_component	GO:0005782	peroxisomal matrix	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004760	serine-pyruvate transaminase activity	IBA
molecular_function	GO:0005102	signaling receptor binding	IEA
molecular_function	GO:0008453	alanine-glyoxylate transaminase activity	ISO
molecular_function	GO:0008483	transaminase activity	ISO
molecular_function	GO:0016597	amino acid binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0030170	pyridoxal phosphate binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:0043621	protein self-association	IEA

Pathways (from Reactome)

Pathway description

Glyoxylate metabolism and glycine degradation

Peroxisomal protein import

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003197	kidney calcification	"pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Ctsg^{tm2(PML/RARA)Ley}/Ctsg^{tm2(PML/RARA)Ley} Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Agxt^tm1Ull/Agxt^tm1Ull Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003606	kidney failure	"cessation of renal function" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Ctsg^{tm2(PML/RARA)Ley}/Ctsg^{tm2(PML/RARA)Ley} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005360	urolithiasis	"presence of calculi in any part of the urinary system" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85461, J:85462]	Show Allelic Composition: Ctsg^{tm2(PML/RARA)Ley}/Ctsg^{tm2(PML/RARA)Ley} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005558	decreased creatinine clearance	"less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ctsg^{tm2(PML/RARA)Ley}/Ctsg^{tm2(PML/RARA)Ley} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agxt^tm1Ull/Agxt^tm1Ull Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0009645	crystalluria	"excretion of crystalline material in the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ctsg^{tm2(PML/RARA)Ley}/Ctsg^{tm2(PML/RARA)Ley} Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011517	hyperoxaluria	"abnormally high levels of oxalic acid or oxalates in the urine; many metal ions form insoluble precipitates with oxalate, a prominent example being calcium oxalate, the primary constituent of the most common kind of kidney stones" [MGI:anna]	Show Allelic Composition: Ctsg^{tm2(PML/RARA)Ley}/Ctsg^{tm2(PML/RARA)Ley} Genetic Background: involves: 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000026272	Agxt / O35423 / Serine--pyruvate aminotransferase, mitochondrial / P21549* / alanine-glyoxylate aminotransferase*	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr