ENSMUSG00000026322


Mus musculus

Features
Gene ID: ENSMUSG00000026322
  
Biological name :Htr4
  
Synonyms : 5 hydroxytryptamine (serotonin) receptor 4 / Htr4 / P97288
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 4 / Q13639
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E1
Gene start: 62324204
Gene end: 62467802
  
Corresponding Affymetrix probe sets: 10456161 (MoGene1.0st)   1427654_a_at (Mouse Genome 430 2.0 Array)   1443365_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027560
NCBI entrez gene - 15562     See in Manteia.
MGI - MGI:109246
RefSeq - XM_017317839
RefSeq - NM_008313
RefSeq - XM_006525683
RefSeq - XM_011246848
RefSeq - XM_006525676
RefSeq - XM_006525678
RefSeq - XM_006525680
RefSeq - XM_006525681
RefSeq - XM_006525682
RefSeq Peptide - NP_032339
swissprot - P97288
Ensembl - ENSMUSG00000026322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr4ENSDARG00000061940Danio rerio
 HTR4ENSGALG00000001383Gallus gallus
 HTR4ENSG00000164270Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Taar4 / Q5QD15 / Trace amine-associated receptor 4 ENSMUSG0000006970731
Taar1 / Q923Y8 / Trace amine-associated receptor 1 / Q96RJ0*ENSMUSG0000005637929
Taar9 / Q5QD04 / Trace amine-associated receptor 9 / Q96RI9* / trace amine associated receptor 9 (gene/pseudogene)*ENSMUSG0000003742428
Q5QD11 / Taar7b / Trace amine-associated receptor 7b ENSMUSG0000009517128
Q5QD09 / Taar7e / trace amine-associated receptor 7EENSMUSG0000010068927
Q5QD10 / Taar7d / Trace amine-associated receptor 7d ENSMUSG0000009556927
Taar2 / Q5QD17 / Trace amine-associated receptor 2 / Q9P1P5* / trace amine associated receptor 2 (gene/pseudogene)*ENSMUSG0000005976327
Taar8a / Q5QD07 / Trace amine-associated receptor 8a / TAAR8* / Q969N4* / trace amine associated receptor 8*ENSMUSG0000009644227
Q5QD12 / Taar7a / Trace amine-associated receptor 7a ENSMUSG0000009564727
Taar8c / Q5QD05 / Trace amine-associated receptor 8c / TAAR8* / Q969N4* / trace amine associated receptor 8*ENSMUSG0000010000427
Taar8b / Q5QD06 / Trace amine-associated receptor 8b / TAAR8* / Q969N4* / trace amine associated receptor 8*ENSMUSG0000010018627
Q5QD08 / Taar7f / Trace amine-associated receptor 7f ENSMUSG0000010095027
Taar5 / Q5QD14 / Trace amine-associated receptor 5 / O14804*ENSMUSG0000006970627
Taar6 / Q5QD13 / Trace amine-associated receptor 6 / Q96RI8*ENSMUSG0000004511126
Taar3 / Q5QD16 / Trace amine-associated receptor 3 ENSMUSG0000006970825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001520  5-Hydroxytryptamine 4 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0032098 regulation of appetite IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ift172wim/Del(5D5Mit73-D5Mit351)5Jcs
Genetic Background: involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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