ENSMUSG00000026341


Mus musculus

Features
Gene ID: ENSMUSG00000026341
  
Biological name :Actr3
  
Synonyms : Actin-related protein 3 / Actr3 / Q99JY9
  
Possible biological names infered from orthology : ARP3 actin related protein 3 homolog / P61158
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 125392905
Gene end: 125435727
  
Corresponding Affymetrix probe sets: 10357332 (MoGene1.0st)   1426392_a_at (Mouse Genome 430 2.0 Array)   1434968_a_at (Mouse Genome 430 2.0 Array)   1452051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137503
Ensembl peptide - ENSMUSP00000140953
Ensembl peptide - ENSMUSP00000140535
Ensembl peptide - ENSMUSP00000140082
Ensembl peptide - ENSMUSP00000140000
Ensembl peptide - ENSMUSP00000139886
Ensembl peptide - ENSMUSP00000139674
Ensembl peptide - ENSMUSP00000027579
NCBI entrez gene - 74117     See in Manteia.
MGI - MGI:1921367
RefSeq - NM_023735
RefSeq - NM_001205385
RefSeq - NM_001205386
RefSeq Peptide - NP_001192315
RefSeq Peptide - NP_001192314
RefSeq Peptide - NP_076224
swissprot - A0A087WS98
swissprot - Q99JY9
swissprot - A0A087WRA1
swissprot - A0A087WQ83
swissprot - A0A087WQ14
swissprot - A0A087WPR6
swissprot - A0A087WP86
swissprot - Q3ULF7
Ensembl - ENSMUSG00000026341
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actr3ENSDARG00000091138Danio rerio
 ACTR3ENSGALG00000012159Gallus gallus
 ACTR3ENSG00000115091Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actr3b / Q641P0 / Actin-related protein 3B / Q9P1U1* / ARP3 actin related protein 3 homolog B*ENSMUSG0000005636789


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR015623  Actin-related protein 3
 IPR020902  Actin/actin-like conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007163 establishment or maintenance of cell polarity IGI
 biological_processGO:0008356 asymmetric cell division IGI
 biological_processGO:0016344 meiotic chromosome movement towards spindle pole IGI
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0033206 meiotic cytokinesis IGI
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation ISO
 biological_processGO:0051321 meiotic cell cycle IGI
 biological_processGO:0051653 spindle localization IGI
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0071346 cellular response to interferon-gamma IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005885 Arp2/3 protein complex ISO
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005200 structural constituent of cytoskeleton ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0051015 actin filament binding ISO


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Actr3Gt(A009F03)Vau/Actr3+
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009781 abnormal preimplantation embryo development "an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Ap3d1mh-2J/Ap3d1mh-2J
Genetic Background: involves: C3H/HeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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