ENSMUSG00000026355


Mus musculus

Features
Gene ID: ENSMUSG00000026355
  
Biological name :Mcm6
  
Synonyms : DNA replication licensing factor MCM6 / Mcm6 / P97311
  
Possible biological names infered from orthology : minichromosome maintenance complex component 6 / Q14566
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E3
Gene start: 128331590
Gene end: 128359664
  
Corresponding Affymetrix probe sets: 10357436 (MoGene1.0st)   1416251_at (Mouse Genome 430 2.0 Array)   1438852_x_at (Mouse Genome 430 2.0 Array)   1447756_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027601
Ensembl peptide - ENSMUSP00000140308
NCBI entrez gene - 17219     See in Manteia.
MGI - MGI:1298227
RefSeq - NM_008567
RefSeq - NM_001313695
RefSeq Peptide - NP_001300624
RefSeq Peptide - NP_032593
swissprot - P97311
swissprot - Q3ULG5
swissprot - Q542I2
Ensembl - ENSMUSG00000026355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm6ENSDARG00000057683Danio rerio
 MCM6ENSGALG00000012348Gallus gallus
 MCM6ENSG00000076003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR008049  DNA replication licensing factor Mcm6
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006268 DNA unwinding involved in DNA replication IPI
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0007049 cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0042555 MCM complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003697 single-stranded DNA binding IPI
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029730 Mcm7 / Q61881 / minichromosome maintenance complex component 7 / P33993*  / complex
 ENSMUSG00000022673 Mcm4 / P49717 / DNA replication licensing factor MCM4 / P33991* / minichromosome maintenance complex component 4*  / complex






 

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