ENSMUSG00000022673


Mus musculus

Features
Gene ID: ENSMUSG00000022673
  
Biological name :Mcm4
  
Synonyms : DNA replication licensing factor MCM4 / Mcm4 / P49717
  
Possible biological names infered from orthology : minichromosome maintenance complex component 4 / P33991
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A2
Gene start: 15623897
Gene end: 15637400
  
Corresponding Affymetrix probe sets: 10437945 (MoGene1.0st)   1416214_at (Mouse Genome 430 2.0 Array)   1436708_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023353
Ensembl peptide - ENSMUSP00000155284
Ensembl peptide - ENSMUSP00000155603
NCBI entrez gene - 17217     See in Manteia.
MGI - MGI:103199
RefSeq - NM_008565
RefSeq Peptide - NP_032591
swissprot - P49717
swissprot - Q542F4
Ensembl - ENSMUSG00000022673
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm4ENSDARG00000040041Danio rerio
 ENSGALG00000012915Gallus gallus
 MCM4ENSG00000104738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcm8 / Q9CWV1 / DNA helicase MCM8 / Q9UJA3* / minichromosome maintenance 8 homologous recombination repair factor*ENSMUSG0000002735326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR008047  Mini-chromosome maintenance complex protein 4
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006268 DNA unwinding involved in DNA replication IPI
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0007049 cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0042555 MCM complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003697 single-stranded DNA binding IPI
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atoh1tm2Hzo/Atoh1+,Gfi1tm1Sho/Gfi1tm1Sho
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg

Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Mc1rtm1.1(KOMP)Vlcg/Mc1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mc1rtm1.1(KOMP)Vlcg/Ucd

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: C3.B6-Mcm4chaos3

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Glrbspa-Alb/Glrbspa-Alb
Genetic Background: C57BL/6Fla-H2-T18

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm4chaos3/Mcm4chaos3,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026355 Mcm6 / P97311 / DNA replication licensing factor MCM6 / Q14566* / minichromosome maintenance complex component 6*  / complex
 ENSMUSG00000029730 Mcm7 / Q61881 / minichromosome maintenance complex component 7 / P33993*  / complex






 

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