ENSDARG00000040041


Danio rerio

Features
Gene ID: ENSDARG00000040041
  
Biological name :mcm4
  
Synonyms : mcm4 / minichromosome maintenance complex component 4
  
Possible biological names infered from orthology : DNA replication licensing factor MCM4 / P33991 / P49717
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 35536664
Gene end: 35561672
  
Corresponding Affymetrix probe sets: Dr.5091.1.S1_at (Zebrafish Array)   NM_198913_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000058563
NCBI entrez gene - 337598     See in Manteia.
RefSeq - NM_198913
RefSeq Peptide - NP_944595
swissprot - Q6NZV2
ZFIN ID - ZDB-GENE-030131-9544
Ensembl - ENSDARG00000040041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000012915Gallus gallus
 MCM4ENSG00000104738Homo sapiens
 Mcm4ENSMUSG00000022673Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mcm8 / minichromosome maintenance 8 homologous recombination repair factor / Q9CWV1* / Q9UJA3* / DNA helicase MCM8 *ENSDARG0000007432626


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR003593  AAA+ ATPase domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001878 response to yeast IDA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0042555 MCM complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000057683 mcm6 / minichromosome maintenance complex component 6 / P97311* / Q14566* / DNA replication licensing factor MCM6 *  / complex






 

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