ENSMUSG00000027353


Mus musculus

Features
Gene ID: ENSMUSG00000027353
  
Biological name :Mcm8
  
Synonyms : DNA helicase MCM8 / Mcm8 / Q9CWV1
  
Possible biological names infered from orthology : minichromosome maintenance 8 homologous recombination repair factor / Q9UJA3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F2
Gene start: 132816141
Gene end: 132844197
  
Corresponding Affymetrix probe sets: 10476362 (MoGene1.0st)   1429557_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028831
Ensembl peptide - ENSMUSP00000066842
NCBI entrez gene - 66634     See in Manteia.
MGI - MGI:1913884
RefSeq - XM_006500021
RefSeq - NM_001291054
RefSeq - NM_025676
RefSeq Peptide - NP_079952
RefSeq Peptide - NP_001277983
swissprot - Q9CWV1
Ensembl - ENSMUSG00000027353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm8ENSDARG00000074326Danio rerio
 MCM8ENSGALG00000009195Gallus gallus
 MCM8ENSG00000125885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcm4 / P49717 / DNA replication licensing factor MCM4 / P33991* / minichromosome maintenance complex component 4*ENSMUSG0000002267327


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR003593  AAA+ ATPase domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007292 female gamete generation IMP
 biological_processGO:0048232 male gamete generation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0097362 MCM8-MCM9 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011129 decreased secondary ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0013539 increased ovary adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the ovary, occurring in a specific population in a given time period" [MGI:Anna]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026037 Orc2 / Q60862 / Origin recognition complex subunit 2 / Q13416*  / complex






 

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