ENSGALG00000009195


Gallus gallus

Features
Gene ID: ENSGALG00000009195
  
Biological name :MCM8
  
Synonyms : DNA helicase MCM8 / I0IUP3 / MCM8
  
Possible biological names infered from orthology : minichromosome maintenance 8 homologous recombination repair factor / Q9CWV1 / Q9UJA3
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 16925328
Gene end: 16940504
  
Corresponding Affymetrix probe sets: Gga.5738.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000014959
Ensembl peptide - ENSGALP00000059238
NCBI entrez gene - 421314     See in Manteia.
RefSeq - NM_001293169
RefSeq Peptide - NP_001280098
swissprot - I0IUP3
Ensembl - ENSGALG00000009195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm8ENSDARG00000074326Danio rerio
 MCM8ENSG00000125885Homo sapiens
 Mcm8ENSMUSG00000027353Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MCM4* / P33991* / P49717* / DNA replication licensing factor MCM4 * / minichromosome maintenance complex component 4*ENSGALG0000001291526


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR003593  AAA+ ATPase domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IDA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007292 female gamete generation IEA
 biological_processGO:0048232 male gamete generation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0097362 MCM8-MCM9 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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