ENSMUSG00000026628


Mus musculus

Features
Gene ID: ENSMUSG00000026628
  
Biological name :Atf3
  
Synonyms : Atf3 / Cyclic AMP-dependent transcription factor ATF-3 / Q60765
  
Possible biological names infered from orthology : activating transcription factor 3 / P18847
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 191170296
Gene end: 191218039
  
Corresponding Affymetrix probe sets: 10361091 (MoGene1.0st)   1449363_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027941
Ensembl peptide - ENSMUSP00000141492
NCBI entrez gene - 11910     See in Manteia.
MGI - MGI:109384
RefSeq - NM_007498
RefSeq Peptide - NP_031524
swissprot - Q4FJW1
swissprot - Q60765
Ensembl - ENSMUSG00000026628
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf3ENSDARG00000007823Danio rerio
 ATF3ENSGALG00000025887Gallus gallus
 ATF3ENSG00000162772Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jdp2 / P97875 / Jun dimerization protein 2 / Q8WYK2*ENSMUSG0000003427145


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029812  cAMP-dependent transcription factor ATF-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006094 gluconeogenesis IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway ISO
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:1990622 CHOP-ATF3 complex ISO
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Atf3tm1.1Hai/Atf3tm1.1Hai,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Atf3tm1Dron/Atf3tm1Dron,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dmdtm1.1Khan/Y
Genetic Background: involves: C57BL/6 * CBA

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tg(Upk2-cre,-EGFP)#Akli/0
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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