ENSMUSG00000026815


Mus musculus

Features
Gene ID: ENSMUSG00000026815
  
Biological name :Gfi1b
  
Synonyms : Gfi1b / O70237 / Zinc finger protein Gfi-1b
  
Possible biological names infered from orthology : growth factor independent 1B transcriptional repressor / Q5VTD9
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 28609450
Gene end: 28621982
  
Corresponding Affymetrix probe sets: 10481304 (MoGene1.0st)   1420399_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028156
Ensembl peptide - ENSMUSP00000128052
NCBI entrez gene - 14582     See in Manteia.
MGI - MGI:1276578
RefSeq - NM_001160406
RefSeq - NM_008114
RefSeq Peptide - NP_001153878
RefSeq Peptide - NP_032140
swissprot - O70237
swissprot - B7ZNH2
Ensembl - ENSMUSG00000026815
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfi1bENSDARG00000079947Danio rerio
 GFI1BENSGALG00000003478Gallus gallus
 GFI1BENSG00000165702Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gfi1 / growth factor independent 1 transcriptional repressor / Q99684*ENSMUSG0000002927555
Fezf2 / Q9ESP5 / Fez family zinc finger protein 2 / Q8TBJ5* / FEZ family zinc finger 2*ENSMUSG0000002174328
Fezf1 / Q0VDQ9 / Fez family zinc finger protein 1 / A0PJY2* / FEZ family zinc finger 1*ENSMUSG0000002969727
Q8BGV5 / Zfp128 / zinc finger protein 128 / ZNF8* / P17098* / zinc finger protein 8*ENSMUSG0000006039724


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily
 IPR037044  Zinc finger protein Gfi-1b


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030854 positive regulation of granulocyte differentiation IDA
 biological_processGO:0045646 regulation of erythrocyte differentiation IMP
 biological_processGO:0051572 negative regulation of histone H3-K4 methylation IMP
 biological_processGO:0051574 positive regulation of histone H3-K9 methylation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000215 absent erythrocytes "lack of mature red blood cells" [J:23061]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
Show

Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gfi1btm1.1Haho/Gfi1btm1.1Haho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Smchd1Gt(AD0165)Wtsi/Smchd1Gt(AD0165)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ifngr1tm1.1Rds/Ifngr1tm1.1Rds,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gfi1btm1.1Haho/Gfi1btm1.1Haho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfi1btm1.1Haho/Gfi1btm1.1Haho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Gfi1btm1.1Haho/Gfi1btm1.1Haho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003714 absence of platelets "lack of non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfi1btm1.1Haho/Gfi1btm1.1Haho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmnatm3Lgf/Lmnatm3Lgf
Genetic Background: involves: 129P2/OlaHsd

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gfi1btm1.1Haho/Gfi1btm1.1Haho,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Col1a1tm1(tetO-cre)Haho/?,Gfi1btm1.1Haho/Gfi1btm1.1Haho
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Wnt3tm1Amc/Wnt3tm1Amc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gfi1btm1Tmo/Gfi1btm1Tmo
Genetic Background: B6.129-Gfi1btm1Tmo

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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