ENSMUSG00000021743


Mus musculus

Features
Gene ID: ENSMUSG00000021743
  
Biological name :Fezf2
  
Synonyms : Fezf2 / Fez family zinc finger protein 2 / Q9ESP5
  
Possible biological names infered from orthology : FEZ family zinc finger 2 / Q8TBJ5
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A1
Gene start: 12342094
Gene end: 12348189
  
Corresponding Affymetrix probe sets: 10417620 (MoGene1.0st)   1418790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153090
Ensembl peptide - ENSMUSP00000153647
Ensembl peptide - ENSMUSP00000022262
NCBI entrez gene - 54713     See in Manteia.
MGI - MGI:1859823
RefSeq - NM_080433
RefSeq Peptide - NP_536681
swissprot - A0A286YDZ2
swissprot - Q9ESP5
Ensembl - ENSMUSG00000021743
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fezf2ENSDARG00000070677Danio rerio
 FEZF2ENSGALG00000007184Gallus gallus
 FEZF2ENSG00000153266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fezf1 / Q0VDQ9 / Fez family zinc finger protein 1 / A0PJY2* / FEZ family zinc finger 1*ENSMUSG0000002969756
Q8BGV5 / Zfp128 / zinc finger protein 128 / ZNF8* / P17098* / zinc finger protein 8*ENSMUSG0000006039724
Gfi1 / growth factor independent 1 transcriptional repressor / Q99684*ENSMUSG0000002927523
Gfi1b / O70237 / Zinc finger protein Gfi-1b / Q5VTD9* / growth factor independent 1B transcriptional repressor*ENSMUSG0000002681522


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0021797 forebrain anterior/posterior pattern specification IGI
 biological_processGO:0021853 cerebral cortex GABAergic interneuron migration IMP
 biological_processGO:0021895 cerebral cortex neuron differentiation IMP
 biological_processGO:0021902 commitment of neuronal cell to specific neuron type in forebrain IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0043697 cell dedifferentiation IGI
 biological_processGO:0045665 negative regulation of neuron differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048664 neuron fate determination IDA
 biological_processGO:0050767 regulation of neurogenesis IGI
 biological_processGO:1902667 regulation of axon guidance IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Lama1tm1.1Olf/Lama1tm1.1Olf
Genetic Background: involves: 129S2/SvPas

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
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Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Isl2tm3.1(Mnx1-Lhx3)Slp/Isl2+
Genetic Background: Not Specified

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1.1Olf/Lama1tm1.1Olf
Genetic Background: involves: 129S2/SvPas

 MP:0002243 abnormal vomeronasal organ morphology "any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fezf1tm1.1Bche/Fezf1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkab2Gt(AL0483)Wtsi/Prkab2Gt(AL0483)Wtsi
Genetic Background: B6.129P2-Prkab2Gt(AL0483)Wtsi

Allelic Composition: Fezf2tm1.1Nses/Fezf2tm1.1Nses,Emx1tm1(cre)Ito/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Lama1tm1.1Olf/Lama1tm1.1Olf
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ephb1tm1Dgen/Ephb1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129

Allelic Composition: Ephb1tm1Dgen/Ephb1tm1Dgen,Fezf2tm1Skm/Fezf2+
Genetic Background: involves: 129

Allelic Composition: Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama1tm1.1Olf/Lama1tm1.1Olf
Genetic Background: involves: 129S2/SvPas

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: Fezf1tm1.1Bche/Fezf1tm1.1Bche,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

 MP:0008228 increased anterior commissure size "enlarged round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ephb1tm1Dgen/Ephb1tm1Dgen,Fezf2tm1Skm/Fezf2+
Genetic Background: involves: 129

Allelic Composition: Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008267 abnormal hippocampus CA3 region morphology 
Show

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011679 abnormal vomeronasal sensory neuron morphology "any structural anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals" [MGI:csmith]
Show

Allelic Composition: Fezf1tm1.1Bche/Fezf1tm1.1Bche,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fezf1tm1.1Bche/Fezf1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129

 MP:0012484 decreased corticospinal tract size "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ephb1tm1Dgen/Ephb1tm1Dgen,Fezf2tm1Skm/Fezf2+
Genetic Background: involves: 129

 MP:0013595 absent vomeronasal organ "lacking the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [MGI:csmith]
Show

Allelic Composition: Fezf1tm1.1Bche/Fezf1tm1.1Bche,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fezf1tm1.1Bche/Fezf1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

 MP:0013597 small vomeronasal organ "reduced size of the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/senses/jacobsonorgan.html, http://en.wikipedia.org/wiki/Vomeronasal_organ#Structure, MGI:csmith]
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Allelic Composition: Fezf1tm1.1Bche/Fezf1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129 * CD-1

Allelic Composition: Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
Show

Allelic Composition: Fezf1tm1Hibi/Fezf1tm1Hibi,Fezf2tm1Hibi/Fezf2tm1Hibi
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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