ENSDARG00000070677


Danio rerio

Features
Gene ID: ENSDARG00000070677
  
Biological name :fezf2
  
Synonyms : fezf2 / FEZ family zinc finger 2 / Q804Q5
  
Possible biological names infered from orthology : Fez family zinc finger protein 2 / Q8TBJ5 / Q9ESP5
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 20056732
Gene end: 20059407
  
Corresponding Affymetrix probe sets: Dr.10670.1.S1_at (Zebrafish Array)   NM_131636_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000094772
Ensembl peptide - ENSDARP00000156395
NCBI entrez gene - 60634     See in Manteia.
RefSeq - NM_131636
RefSeq - XM_005155838
RefSeq Peptide - NP_571711
swissprot - Q804Q5
swissprot - G1K2U0
ZFIN ID - ZDB-GENE-001103-3
Ensembl - ENSDARG00000070677
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FEZF2ENSGALG00000007184Gallus gallus
 FEZF2ENSG00000153266Homo sapiens
 Fezf2ENSMUSG00000021743Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fezf1 / Q25C93 / FEZ family zinc finger 1 / Q0VDQ9* / A0PJY2* / Fez family zinc finger protein 1 *ENSDARG0000001027050
gfi1ab / growth factor independent 1A transcription repressor b / GFI1* / Q99684* / growth factor independent 1 transcriptional repressor*ENSDARG0000004445723
gfi1aa / growth factor independent 1A transcription repressor a / GFI1* / Q99684* / growth factor independent 1 transcriptional repressor*ENSDARG0000002074621
gfi1b / growth factor independent 1B transcription repressor / O70237* / Q5VTD9* / Zinc finger protein Gfi-1b * / growth factor independent 1B transcriptional repressor*ENSDARG0000007994720


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0021536 diencephalon development IMP
 biological_processGO:0021767 mammillary body development IMP
 biological_processGO:0021854 hypothalamus development IMP
 biological_processGO:0021879 forebrain neuron differentiation IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000032 hypothalamus hypothalamus has fewer parts of type neurosecretory neuron , abnormal
hypothalamus has fewer parts of type dopaminergic neuron , abnormal
hypothalamus dopaminergic neuron decreased amount , abnormal
hypothalamus physical object quality , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000079 telencephalon telencephalon decreased size , abnormal
telencephalon lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0000109 forebrain forebrain dopaminergic neuron decreased amount , abnormal
forebrain serotonergic neuron decreased amount , abnormal
Show

 ZFA:0000152 retina retina lacks parts or has fewer parts of type dopaminergic neuron , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000458 ventral thalamus ventral thalamus decreased size , abnormal
Show

 ZFA:0000470 preoptic area preoptic area physical object quality , abnormal
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 ZFA:0000505 dorsal telencephalon dorsal telencephalon neuronal stem cell proliferative , abnormal
dorsal telencephalon Notch signaling pathway decreased process quality , abnormal
dorsal telencephalon neuron projection decreased branchiness , abnormal
dorsal telencephalon neuron projection morphogenesis decreased occurrence , abnormal
dorsal telencephalon has extra parts of type neuron , abnormal
dorsal telencephalon neurogenesis increased occurrence , abnormal
dorsal telencephalon neuron immature , abnormal
Show

 ZFA:0000539 locus coeruleus locus coeruleus lacks parts or has fewer parts of type neuron , abnormal
Show

 ZFA:0000633 caudal tuberculum caudal tuberculum physical object quality , abnormal
Show

 ZFA:0001083 ventricular zone ventricular zone Notch signaling pathway decreased process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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