ENSMUSG00000026965


Mus musculus

Features
Gene ID: ENSMUSG00000026965
  
Biological name :Anapc2
  
Synonyms : Anapc2 / Anaphase-promoting complex subunit 2 / Q8BZQ7
  
Possible biological names infered from orthology : Q9UJX6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 25272478
Gene end: 25285915
  
Corresponding Affymetrix probe sets: 10469965 (MoGene1.0st)   10338383 (MoGene1.0st)   10338528 (MoGene1.0st)   10338974 (MoGene1.0st)   10339216 (MoGene1.0st)   10339530 (MoGene1.0st)   10339692 (MoGene1.0st)   10339988 (MoGene1.0st)   10340427 (MoGene1.0st)   10341316 (MoGene1.0st)   10341861 (MoGene1.0st)   10342641 (MoGene1.0st)   10343019 (MoGene1.0st)   10343221 (MoGene1.0st)   10343299 (MoGene1.0st)   10344279 (MoGene1.0st)   10338218 (MoGene1.0st)   10338341 (MoGene1.0st)   10338462 (MoGene1.0st)   10339581 (MoGene1.0st)   10339728 (MoGene1.0st)   10341706 (MoGene1.0st)   10343150 (MoGene1.0st)   10343231 (MoGene1.0st)   10343571 (MoGene1.0st)   10343608 (MoGene1.0st)   10343838 (MoGene1.0st)   1415707_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115177
Ensembl peptide - ENSMUSP00000028341
NCBI entrez gene - 99152     See in Manteia.
MGI - MGI:2139135
RefSeq - NM_175300
RefSeq Peptide - NP_780509
swissprot - A2AI11
swissprot - Q8BZQ7
Ensembl - ENSMUSG00000026965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anapc2ENSDARG00000105035Danio rerio
 ANAPC2ENSGALG00000008625Gallus gallus
 ANAPC2ENSG00000176248Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR014786  Anaphase-promoting complex subunit 2, C-terminal
 IPR016158  Cullin homology domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031915 positive regulation of synaptic plasticity IDA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070979 protein K11-linked ubiquitination IEA
 biological_processGO:0090129 positive regulation of synapse maturation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Anapc2tm1Kna/Anapc2tm1Kna,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Anapc2tm1Kna/Anapc2tm1Kna,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad/Myo5ad-97H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Anapc2tm1Kna/Anapc2tm1Kna,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Anapc2tm1Kna/Anapc2tm1Kna,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gria2tm2Rsp/Gria2+,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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