ENSMUSG00000027187


Mus musculus

Features
Gene ID: ENSMUSG00000027187
  
Biological name :Cat
  
Synonyms : Cat / Catalase / P24270
  
Possible biological names infered from orthology : P04040
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E2
Gene start: 103453849
Gene end: 103485160
  
Corresponding Affymetrix probe sets: 10485466 (MoGene1.0st)   1416429_a_at (Mouse Genome 430 2.0 Array)   1416430_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106798
Ensembl peptide - ENSMUSP00000028610
NCBI entrez gene - 12359     See in Manteia.
MGI - MGI:88271
RefSeq - NM_009804
RefSeq Peptide - NP_033934
swissprot - A2AL20
swissprot - P24270
Ensembl - ENSMUSG00000027187
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 catENSDARG00000104702Danio rerio
 CATENSGALG00000030187Gallus gallus
 CATENSG00000121691Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002226  Catalase haem-binding site
 IPR010582  Catalase immune-responsive domain
 IPR011614  Catalase core domain
 IPR018028  Catalase, mono-functional, haem-containing
 IPR020835  Catalase superfamily
 IPR024708  Catalase active site
 IPR024711  Catalase, mono-functional, haem-containing, clades 1 and 3
 IPR037060  Catalase core domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0009060 aerobic respiration IMP
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009642 response to light intensity IEA
 biological_processGO:0009650 UV protection IEA
 biological_processGO:0010193 response to ozone IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014854 response to inactivity IEA
 biological_processGO:0020027 hemoglobin metabolic process IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0033591 response to L-ascorbic acid IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IBA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0080184 response to phenylpropanoid IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005778 peroxisomal membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004046 aminoacylase activity IMP
 molecular_functionGO:0004096 catalase activity IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016684 oxidoreductase activity, acting on peroxide as acceptor IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
Neutrophil degranulation
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0003186 abnormal redox activity "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

Allelic Composition: Catc/Catc
Genetic Background: Not Specified

Allelic Composition: Catd/Catd
Genetic Background: Not Specified

Allelic Composition: Cate/Cate
Genetic Background: Not Specified

Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu

Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0010264 increased hepatoma incidence "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

 MP:0011592 abnormal catalase activity "anomaly in the ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O" [GO:0004096]
Show

Allelic Composition: Grm1rcw-4J/Grm1rcw-4J
Genetic Background: C57BL/6J-Grm1rcw-4J/GrsrJ

Allelic Composition: Catc/Catc
Genetic Background: Not Specified

Allelic Composition: Catd/Catd
Genetic Background: Not Specified

Allelic Composition: Cate/Cate
Genetic Background: Not Specified

Allelic Composition: Catf/Catf
Genetic Background: Not Specified

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027187 Cat / P24270 / Catalase / P04040*  / complex






 

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