ENSMUSG00000027199


Mus musculus

Features
Gene ID: ENSMUSG00000027199
  
Biological name :Gatm
  
Synonyms : Gatm / Glycine amidinotransferase, mitochondrial / Q9D964
  
Possible biological names infered from orthology : glycine amidinotransferase / P50440
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 122594467
Gene end: 122611303
  
Corresponding Affymetrix probe sets: 10487011 (MoGene1.0st)   1423569_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028624
NCBI entrez gene - 67092     See in Manteia.
MGI - MGI:1914342
RefSeq - NM_025961
RefSeq Peptide - NP_080237
swissprot - Q9D964
Ensembl - ENSMUSG00000027199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gatmENSDARG00000036239Danio rerio
 GATMENSGALG00000023435Gallus gallus
 GATMENSG00000171766Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR033195  Glycine/inosamine-phosphate amidinotransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006600 creatine metabolic process IEA
 biological_processGO:0006601 creatine biosynthetic process IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0014889 muscle atrophy IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0015067 amidinotransferase activity IBA
 molecular_functionGO:0015068 glycine amidinotransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Creatine metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gatmem1Btlr/Gatmem1Btlr
Genetic Background: C57BL/6J-Gatmem1Btlr

Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

Allelic Composition: Gatmem1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmem1Btlr/Gatmm1Btlr

Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

Allelic Composition: Gatmm1Btlr/Gatm+
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tap2m3Btlr/Tap2m3Btlr
Genetic Background: C57BL/6J-Tap2m3Btlr

Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

Allelic Composition: Gatmm1Btlr/Gatm+
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0010062 decreased creatine concentration "reduction in the amount per unit of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

Allelic Composition: Gatmem1Btlr/Gatmem1Btlr
Genetic Background: C57BL/6J-Gatmem1Btlr

Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0010068 decreased red blood cell distribution width "lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gatmem1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmem1Btlr/Gatmm1Btlr

Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0011468 abnormal urine amino acid level "any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709, MGI:csmith]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0011897 decreased circulating unsaturated transferrin level "reduction in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test" [MGI:csmith]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Gatmtm1b(KOMP)Wtsi/Gatmtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gatmtm1b(KOMP)Wtsi/Ieg

 MP:0013482 abnormal duodenum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the duodenum, the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Anna]
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Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: Gatmem1Btlr/Gatmem1Btlr
Genetic Background: C57BL/6J-Gatmem1Btlr

Allelic Composition: Gatmem1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmem1Btlr/Gatmm1Btlr

Allelic Composition: Gatmm1Btlr/Gatmm1Btlr
Genetic Background: C57BL/6J-Gatmm1Btlr

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Trpv5m1Btlr/Trpv5m1Btlr
Genetic Background: C57BL/6J-Trpv5m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027199 Gatm / Q9D964 / Glycine amidinotransferase, mitochondrial / P50440* / glycine amidinotransferase*  / complex






 

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