ENSMUSG00000027339


Mus musculus

Features
Gene ID: ENSMUSG00000027339
  
Biological name :Rassf2
  
Synonyms : Q8BMS9 / Ras association domain-containing protein 2 / Rassf2
  
Possible biological names infered from orthology : P50749 / Ras association domain family member 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F2
Gene start: 131989415
Gene end: 132030258
  
Corresponding Affymetrix probe sets: 10487894 (MoGene1.0st)   1428392_at (Mouse Genome 430 2.0 Array)   1443998_at (Mouse Genome 430 2.0 Array)   1444889_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120194
Ensembl peptide - ENSMUSP00000028814
Ensembl peptide - ENSMUSP00000099471
Ensembl peptide - ENSMUSP00000117619
NCBI entrez gene - 215653     See in Manteia.
MGI - MGI:2442060
RefSeq - XM_006499144
RefSeq - XM_006499140
RefSeq - XM_006499141
RefSeq - XM_006499142
RefSeq - XM_006499143
RefSeq - NM_175445
RefSeq - XM_006499139
RefSeq Peptide - NP_780654
swissprot - A2AVI0
swissprot - A2APB1
swissprot - Q8BMS9
Ensembl - ENSMUSG00000027339
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rassf2aENSDARG00000029865Danio rerio
 rassf2bENSDARG00000044044Danio rerio
 RASSF2ENSGALG00000030432Gallus gallus
 P50749ENSG00000101265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CB96 / Rassf4 / Ras association domain-containing protein 4 / Q9H2L5* / Ras association domain family member 4*ENSMUSG0000004212956
Q80UQ2 / Rassf6 / Ras association domain-containing protein 6 / Q6ZTQ3* / Ras association domain family member 6*ENSMUSG0000002937036


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR011524  SARAH domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033614  C-terminal RASSF family
 IPR033618  Ras association domain-containing protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation ISO
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0038168 epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0045667 regulation of osteoblast differentiation IMP
 biological_processGO:0045670 regulation of osteoclast differentiation IMP
 biological_processGO:0045860 positive regulation of protein kinase activity ISO
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0046849 bone remodeling IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0009544 abnormal thymus epithelium morphology "any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh4arl/Myh4arl
Genetic Background: involves: C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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