ENSMUSG00000027376


Mus musculus

Features
Gene ID: ENSMUSG00000027376
  
Biological name :Prom2
  
Synonyms : Prom2 / Prominin-2 / Q3UUY6
  
Possible biological names infered from orthology : Q8N271
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 127526473
Gene end: 127541467
  
Corresponding Affymetrix probe sets: 10487405 (MoGene1.0st)   1417047_at (Mouse Genome 430 2.0 Array)   1417048_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028855
Ensembl peptide - ENSMUSP00000099503
NCBI entrez gene - 192212     See in Manteia.
MGI - MGI:2138997
RefSeq - NM_138750
RefSeq - NM_178047
RefSeq Peptide - NP_620089
RefSeq Peptide - NP_835148
swissprot - Q3UUY6
Ensembl - ENSMUSG00000027376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prom2ENSDARG00000039406Danio rerio
 PROM2ENSGALG00000041347Gallus gallus
 PROM2ENSG00000155066Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prom1 / prominin 1 / O43490*ENSMUSG0000002908628


Protein motifs (from Interpro)
Interpro ID Name
 IPR008795  Prominin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0031346 positive regulation of cell projection organization ISO
 biological_processGO:0043087 regulation of GTPase activity ISO
 biological_processGO:0048550 negative regulation of pinocytosis ISO
 biological_processGO:2001287 negative regulation of caveolin-mediated endocytosis ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0005929 cilium ISS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0042995 cell projection ISO
 cellular_componentGO:0044393 microspike ISS
 cellular_componentGO:0045121 membrane raft ISS
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0071914 prominosome IDA
 molecular_functionGO:0015485 cholesterol binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Setd7tm1.1Ital/Setd7tm1.1Ital
Genetic Background: involves: C57BL/6 * CBA

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Setd7tm1.1Ital/Setd7tm1.1Ital
Genetic Background: involves: C57BL/6 * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Setd7tm1.1Ital/Setd7tm1.1Ital
Genetic Background: involves: C57BL/6 * CBA

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prom2tm1.1(KOMP)Vlcg/Prom2+
Genetic Background: C57BL/6N-Prom2tm1.1(KOMP)Vlcg/J

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

Allelic Composition: Prom2tm1.1(KOMP)Vlcg/Prom2+
Genetic Background: C57BL/6N-Prom2tm1.1(KOMP)Vlcg/J

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Setd7tm1.1Ital/Setd7tm1.1Ital
Genetic Background: involves: C57BL/6 * CBA

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Pitx3tm1.1(KOMP)Vlcg/Pitx3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Pitx3tm1.1(KOMP)Vlcg/J

 MP:0013513 decreased memory-marker CD4-negative NK T cell number "reduction in the number of memory-marker CD4-negative NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran]
Show

Allelic Composition: Prom2tm1.1(KOMP)Vlcg/Prom2+
Genetic Background: C57BL/6N-Prom2tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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