ENSMUSG00000029086


Mus musculus

Features
Gene ID: ENSMUSG00000029086
  
Biological name :Prom1
  
Synonyms : Prom1 / prominin 1
  
Possible biological names infered from orthology : O43490
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B3
Gene start: 43993620
Gene end: 44102032
  
Corresponding Affymetrix probe sets: 10529824 (MoGene1.0st)   1419700_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137557
Ensembl peptide - ENSMUSP00000136483
Ensembl peptide - ENSMUSP00000142375
Ensembl peptide - ENSMUSP00000143403
Ensembl peptide - ENSMUSP00000142677
Ensembl peptide - ENSMUSP00000142632
Ensembl peptide - ENSMUSP00000142483
Ensembl peptide - ENSMUSP00000030973
Ensembl peptide - ENSMUSP00000073751
Ensembl peptide - ENSMUSP00000084707
Ensembl peptide - ENSMUSP00000084709
Ensembl peptide - ENSMUSP00000128978
Ensembl peptide - ENSMUSP00000129909
NCBI entrez gene - 19126     See in Manteia.
MGI - MGI:1100886
RefSeq - XM_017320725
RefSeq - NM_001163577
RefSeq - NM_001163578
RefSeq - NM_001163581
RefSeq - NM_001163582
RefSeq - NM_001163583
RefSeq - NM_001163584
RefSeq - NM_001163585
RefSeq - NM_008935
RefSeq - XM_006503786
RefSeq - XM_006503788
RefSeq - XM_006503789
RefSeq - XM_006503790
RefSeq - XM_006503791
RefSeq - XM_017320720
RefSeq - XM_017320722
RefSeq - XM_017320723
RefSeq - XM_017320724
RefSeq Peptide - NP_001157050
RefSeq Peptide - NP_001157054
RefSeq Peptide - NP_001157055
RefSeq Peptide - NP_001157056
RefSeq Peptide - NP_001157057
RefSeq Peptide - NP_032961
RefSeq Peptide - NP_001157049
RefSeq Peptide - NP_001157053
swissprot - Q8R056
swissprot - A0A0G2JDH9
swissprot - Q8CDK8
swissprot - A0A0R4J0B0
swissprot - A0A0G2JG30
swissprot - A0A0G2JE90
swissprot - A0A0G2JE50
swissprot - G3X9J8
swissprot - G5E8G5
swissprot - A0A0G2JDS7
Ensembl - ENSMUSG00000029086
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prom1aENSDARG00000039966Danio rerio
 prom1bENSDARG00000034007Danio rerio
 PROM1ENSGALG00000014496Gallus gallus
 PROM1ENSG00000007062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prom2 / Q3UUY6 / Prominin-2 / Q8N271*ENSMUSG0000002737627


Protein motifs (from Interpro)
Interpro ID Name
 IPR008795  Prominin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045494 photoreceptor cell maintenance IEA
 biological_processGO:0060042 retina morphogenesis in camera-type eye IEA
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IEA
 biological_processGO:0072112 glomerular visceral epithelial cell differentiation IEA
 biological_processGO:0072139 glomerular parietal epithelial cell differentiation IEA
 biological_processGO:2000768 positive regulation of nephron tubule epithelial cell differentiation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042622 photoreceptor outer segment membrane IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0042805 actinin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prom1tm1.1(DTA)Toko/Prom1tm1.1(DTA)Toko
Genetic Background: involves: C57BL/6 * SJL

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Prom1tm1.1(DTA)Toko/Prom1tm1.1(DTA)Toko
Genetic Background: involves: C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rak/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Prom1tm1.1(DTA)Toko/Prom1tm1.1(DTA)Toko
Genetic Background: involves: C57BL/6 * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0002957 intestinal adenocarcinoma "malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Prom1tm1(cre/ERT2)Gilb/Prom1+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmx1mpe/Hmx1mpe
Genetic Background: C3H/HeJ-Hmx1mpe/J

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Prom1rd19/Prom1rd19
Genetic Background: B6.BXD83-Prom1rd19/Boc

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Prom1tm1.1(DTA)Toko/Prom1tm1.1(DTA)Toko
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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