ENSMUSG00000027397


Mus musculus

Features
Gene ID: ENSMUSG00000027397
  
Biological name :Slc20a1
  
Synonyms : Q61609 / Slc20a1 / Sodium-dependent phosphate transporter 1
  
Possible biological names infered from orthology : Q8WUM9 / solute carrier family 20 member 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 129198764
Gene end: 129211616
  
Corresponding Affymetrix probe sets: 10475990 (MoGene1.0st)   1438824_at (Mouse Genome 430 2.0 Array)   1446441_at (Mouse Genome 430 2.0 Array)   1448568_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121074
Ensembl peptide - ENSMUSP00000028880
Ensembl peptide - ENSMUSP00000105944
NCBI entrez gene - 20515     See in Manteia.
MGI - MGI:108392
RefSeq - NM_015747
RefSeq - XM_011239399
RefSeq Peptide - NP_056562
swissprot - B0R035
swissprot - Q61609
Ensembl - ENSMUSG00000027397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc20a1aENSDARG00000020114Danio rerio
 slc20a1bENSDARG00000010641Danio rerio
 SLC20A1ENSGALG00000013740Gallus gallus
 Q8WUM9ENSG00000144136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80UP8 / Slc20a2 / Sodium-dependent phosphate transporter 2 / Q08357* / solute carrier family 20 member 2*ENSMUSG0000003765658


Protein motifs (from Interpro)
Interpro ID Name
 IPR001204  Phosphate transporter


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006817 phosphate ion transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005315 inorganic phosphate transmembrane transporter activity IBA
 molecular_functionGO:0005316 high-affinity inorganic phosphate:sodium symporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015319 sodium:inorganic phosphate symporter activity IBA


Pathways (from Reactome)
Pathway description
Sodium-coupled phosphate cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000314 schistocytosis "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lrrk2tm1.1Cai/Lrrk2tm1.1Cai
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Slc20a1tm1.2Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1.2Lbek
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Slc20a1tm1Lbek/Slc20a1tm1Lbek
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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