ENSMUSG00000027424


Mus musculus

Features
Gene ID: ENSMUSG00000027424
  
Biological name :Mgme1
  
Synonyms : Mgme1 / Mus musculus mitochondrial genome maintenance exonuclease 1 (Mgme1), transcript variant 4, mRNA. / Q9CXC3
  
Possible biological names infered from orthology : mitochondrial genome maintenance exonuclease 1 / Q9BQP7
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G1
Gene start: 144270663
Gene end: 144281227
  
Corresponding Affymetrix probe sets: 10476660 (MoGene1.0st)   1429619_a_at (Mouse Genome 430 2.0 Array)   1429620_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028910
Ensembl peptide - ENSMUSP00000105654
Ensembl peptide - ENSMUSP00000105655
NCBI entrez gene - 74528     See in Manteia.
MGI - MGI:1921778
RefSeq - XM_006500302
RefSeq - NM_001289630
RefSeq - NM_001289631
RefSeq - NM_001355688
RefSeq - NM_028984
RefSeq Peptide - NP_001276560
RefSeq Peptide - NP_001342617
RefSeq Peptide - NP_083260
RefSeq Peptide - NP_001276559
swissprot - Q9CXC3
Ensembl - ENSMUSG00000027424
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgme1ENSDARG00000016656Danio rerio
 MGME1ENSGALG00000008698Gallus gallus
 MGME1ENSG00000125871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011604  Exonuclease, phage-type/RecB, C-terminal
 IPR026970  Mitochondrial genome maintenance exonuclease 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance ISS
 biological_processGO:0006264 mitochondrial DNA replication IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0043504 mitochondrial DNA repair ISS
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008297 single-stranded DNA exodeoxyribonuclease activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot1tm1Tya/Cnot1tm1Tya,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB

Allelic Composition: Mgme1tm1.2Lrsn/Mgme1tm1.2Lrsn
Genetic Background: involves: C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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