Manteia - Molecule gene

ENSMUSG00000027483

Mus musculus

Features

Gene ID:	ENSMUSG00000027483

Biological name :	Bpifa1

Synonyms :	Bpifa1 / BPI fold-containing family A member 1 / P97361

Possible biological names infered from orthology :	Q9NP55

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	H1
Gene start:	154142880
Gene end:	154149219

Corresponding Affymetrix probe sets:	10477475 (MoGene1.0st) 1420347_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000028985 NCBI entrez gene - 18843 See in Manteia. MGI - MGI:1338036 RefSeq - NM_011126 RefSeq Peptide - NP_035256 swissprot - P97361 Ensembl - ENSMUSG00000027483

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
BPIFA1	ENSG00000198183	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Bpifa5 / Q9CQX3 / BPI fold-containing family A member 5 / BPIFA1* / Q9NP55* / BPI fold containing family A member 1*	ENSMUSG00000027484	59
Bpifb1 / Q61114 / BPI fold-containing family B member 1 / Q8TDL5*	ENSMUSG00000027485	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR017942	Lipid-binding serum glycoprotein, N-terminal
IPR017943	Bactericidal permeability-increasing protein, alpha/beta domain superfamily
IPR032942	BPI/LBP/Plunc family
IPR034307	BPI fold-containing family A member 1

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0019731	antibacterial humoral response	IMP
biological_process	GO:0042742	defense response to bacterium	IEA
biological_process	GO:0045087	innate immune response	ISO
biological_process	GO:0050828	regulation of liquid surface tension	ISO
biological_process	GO:0050891	multicellular organismal water homeostasis	ISO
biological_process	GO:1900229	negative regulation of single-species biofilm formation in or on host organism	ISO
biological_process	GO:1902305	regulation of sodium ion transmembrane transport	ISO
cellular_component	GO:0005576	extracellular region	ISO
cellular_component	GO:0005615	extracellular space	ISS
cellular_component	GO:0005902	microvillus	IEA
molecular_function	GO:0003674	molecular_function	ND
molecular_function	GO:0008289	lipid binding	IEA

Pathways (from Reactome)

Pathway description

Antimicrobial peptides

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001850	otitis media	"middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]	Show Allelic Composition: Bpifa1^m1Ingm/Bpifa1^m1Ingm Genetic Background: involves: C3HeB/FeJ
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Bpifa1^m1Ingm/Bpifa1^m1Ingm Genetic Background: involves: C3HeB/FeJ
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2.1(MYC/ERT)Hsc}/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor Allelic Composition: Bpifa1^m1Ingm/Bpifa1^m1Ingm Genetic Background: involves: C3HeB/FeJ
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Bpifa1^m1Ingm/Bpifa1^m1Ingm Genetic Background: involves: C3HeB/FeJ
MP:0008654	increased interleukin-1 alpha secretion	"increase in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]	Show Allelic Composition: Bpifa1^m1Ingm/Bpifa1^m1Ingm Genetic Background: involves: C3HeB/FeJ
MP:0008657	increased interleukin-1 beta secretion	"increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Bpifa1^m1Ingm/Bpifa1^m1Ingm Genetic Background: involves: C3HeB/FeJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr