ENSMUSG00000027499


Mus musculus

Features
Gene ID: ENSMUSG00000027499
  
Biological name :Pkia
  
Synonyms : cAMP-dependent protein kinase inhibitor alpha / P63248 / Pkia
  
Possible biological names infered from orthology : P61925
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A1
Gene start: 7366669
Gene end: 7445366
  
Corresponding Affymetrix probe sets: 10490794 (MoGene1.0st)   1420858_at (Mouse Genome 430 2.0 Array)   1420859_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142120
Ensembl peptide - ENSMUSP00000028999
Ensembl peptide - ENSMUSP00000141466
NCBI entrez gene - 18767     See in Manteia.
MGI - MGI:104747
RefSeq - NM_008862
RefSeq - XM_006530056
RefSeq Peptide - NP_032888
swissprot - A0A0A6YXS7
swissprot - P63248
Ensembl - ENSMUSG00000027499
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PKIAENSGALG00000035525Gallus gallus
 PKIAENSG00000171033Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004171  cAMP-dependent protein kinase inhibitor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0042308 negative regulation of protein import into nucleus IDA
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mtrtm1Lcb/Mtrtm1Lcb
Genetic Background: involves: 129S/SvEv * Black Swiss

Allelic Composition: Pkiatm1Idz/Pkiatm1Idz,Pkibtm1Idz/Pkibtm1Idz
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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