ENSMUSG00000027513


Mus musculus

Features
Gene ID: ENSMUSG00000027513
  
Biological name :Pck1
  
Synonyms : Pck1 / Phosphoenolpyruvate carboxykinase, cytosolic [GTP] / Q9Z2V4
  
Possible biological names infered from orthology : P35558 / phosphoenolpyruvate carboxykinase 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 173153048
Gene end: 173159273
  
Corresponding Affymetrix probe sets: 10479047 (MoGene1.0st)   1423439_at (Mouse Genome 430 2.0 Array)   1439617_s_at (Mouse Genome 430 2.0 Array)   1455209_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029017
NCBI entrez gene - 18534     See in Manteia.
MGI - MGI:97501
RefSeq - NM_011044
RefSeq Peptide - NP_035174
swissprot - Q9Z2V4
Ensembl - ENSMUSG00000027513
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pck1ENSDARG00000013522Danio rerio
 PCK1ENSGALG00000007636Gallus gallus
 PCK1ENSG00000124253Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pck2 / Q8BH04 / Phosphoenolpyruvate carboxykinase [GTP], mitochondrial / Q16822* / phosphoenolpyruvate carboxykinase 2, mitochondrial*ENSMUSG0000004061871


Protein motifs (from Interpro)
Interpro ID Name
 IPR008209  Phosphoenolpyruvate carboxykinase, GTP-utilising
 IPR008210  Phosphoenolpyruvate carboxykinase, N-terminal
 IPR013035  Phosphoenolpyruvate carboxykinase, C-terminal
 IPR018091  Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site
 IPR035077  Phosphoenolpyruvate carboxykinase, GTP-utilising, C-terminal
 IPR035078  Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006094 gluconeogenesis ISO
 biological_processGO:0006107 oxaloacetate metabolic process IEA
 biological_processGO:0006475 internal protein amino acid acetylation IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0046327 glycerol biosynthetic process from pyruvate IMP
 biological_processGO:0051365 cellular response to potassium ion starvation IDA
 biological_processGO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IDA
 biological_processGO:0070741 response to interleukin-6 IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071332 cellular response to fructose stimulus IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1904640 response to methionine IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004611 phosphoenolpyruvate carboxykinase activity IMP
 molecular_functionGO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity ISO
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0017076 purine nucleotide binding IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0031406 carboxylic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pck1tm1Mgn/Pck1tm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pck1tm1Mgn/Pck1tm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Steap3fred/Steap3fred
Genetic Background: C57BL/6-Steap3fred

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009122 decreased white fat cell lipid droplet size "reduction in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009128 decreased brown fat cell number "reduction in the number of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009136 decreased brown fat cell size "reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pck1tm1.1Mgn/Pck1tm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trpv1tm1Jbd/Trpv1tm1Jbd
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Pck1tm1Rwh/Pck1tm1Rwh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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