ENSMUSG00000027676


Mus musculus

Features
Gene ID: ENSMUSG00000027676
  
Biological name :Ccdc39
  
Synonyms : Ccdc39 / Coiled-coil domain-containing protein 39 / Q9D5Y1
  
Possible biological names infered from orthology : coiled-coil domain containing 39 / Q9UFE4
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A3
Gene start: 33812362
Gene end: 33844310
  
Corresponding Affymetrix probe sets: 10497731 (MoGene1.0st)   1429780_at (Mouse Genome 430 2.0 Array)   1429781_s_at (Mouse Genome 430 2.0 Array)   1440504_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029222
NCBI entrez gene - 51938     See in Manteia.
MGI - MGI:1289263
RefSeq - XM_017319641
RefSeq - NM_026222
RefSeq - XM_006535500
RefSeq - XM_011249686
RefSeq - XM_006535498
RefSeq - XM_006535499
RefSeq Peptide - NP_080498
swissprot - Q9D5Y1
Ensembl - ENSMUSG00000027676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01055306.1ENSDARG00000100981Danio rerio
 ENSGALG00000021855Gallus gallus
 CCDC39ENSG00000145075Homo sapiens
 CCDC39ENSG00000284862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily
 IPR033290  Coiled-coil domain-containing protein 39


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping ISO
 biological_processGO:0003341 cilium movement ISO
 biological_processGO:0003356 regulation of cilium beat frequency ISO
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030317 flagellated sperm motility ISO
 biological_processGO:0030324 lung development ISO
 biological_processGO:0035469 determination of pancreatic left/right asymmetry ISO
 biological_processGO:0036159 inner dynein arm assembly ISO
 biological_processGO:0044458 motile cilium assembly ISO
 biological_processGO:0060285 cilium-dependent cell motility ISO
 biological_processGO:0060287 epithelial cilium movement involved in determination of left/right asymmetry ISS
 biological_processGO:0070286 axonemal dynein complex assembly ISO
 biological_processGO:0071907 determination of digestive tract left/right asymmetry ISO
 biological_processGO:0071910 determination of liver left/right asymmetry ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IBA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Ltbp1b2b1000Clo/Ltbp1b2b1000Clo
Genetic Background: C57BL/6J-Ltbp1b2b1000Clo

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Slc47a1Gt(IST12634F2)Tigm/Slc47a1Gt(IST12634F2)Tigm
Genetic Background: B6.B6N-Slc47a1Gt(IST12634F2)Tigm

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp1b2b1000Clo/Ltbp1b2b1000Clo
Genetic Background: C57BL/6J-Ltbp1b2b1000Clo

Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000690 absent spleen "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Slc47a1Gt(IST12634F2)Tigm/Slc47a1Gt(IST12634F2)Tigm
Genetic Background: B6.B6N-Slc47a1Gt(IST12634F2)Tigm

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Ccdc39prh/Ccdc39tm1a(KOMP)Wtsi
Genetic Background: involves: A/J * C57BL/6N * FVB/N

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Ccdc39prh/Ccdc39tm1a(KOMP)Wtsi
Genetic Background: involves: A/J * C57BL/6N * FVB/N

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Raf1tm2.1Ara/Raf1tm2.1Ara
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0006061 right atrial isomerism "altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0008461 left atrial isomerism "anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the left side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltbp1b2b1000Clo/Ltbp1b2b1000Clo
Genetic Background: C57BL/6J-Ltbp1b2b1000Clo

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccdc39prh/Ccdc39tm1a(KOMP)Wtsi
Genetic Background: involves: A/J * C57BL/6N * FVB/N

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0011069 abnormal brain ependyma motile cilium physiology "any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Ccdc39prh/Ccdc39tm1a(KOMP)Wtsi
Genetic Background: involves: A/J * C57BL/6N * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0011249 abdominal situs inversus "lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MGI:csmith]
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Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
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Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Ccdc39b2b1304Clo/Ccdc39b2b1304Clo
Genetic Background: C57BL/6J-Ccdc39b2b1304Clo

Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

 MP:0011254 superior-inferior ventricles "an abnormality in which the heart ventricles are in a superior-inferior relationship due to abnormal displacement of the ventricular mass along the horizontal plane of its long axis; this frequently occurs together with criss-cross atrio-ventricular relationships" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Ccdc39prh/Ccdc39tm1a(KOMP)Wtsi
Genetic Background: involves: A/J * C57BL/6N * FVB/N

 MP:0011649 immotile respiratory cilia "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]
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Allelic Composition: Ccdc39b2b1304Clo/Ccdc39b2b1304Clo
Genetic Background: C57BL/6J-Ccdc39b2b1304Clo

Allelic Composition: Ccdc39b2b1735Clo/Ccdc39b2b1735Clo
Genetic Background: C57BL/6J-Ccdc39b2b1735Clo

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0011668 double outlet right ventricle, Taussig bing type "a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
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Allelic Composition: Ccdc39b2b2025.1Clo/Ccdc39b2b2025.1Clo
Genetic Background: C57BL/6J-Ccdc39b2b2025.1Clo

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0013907 abnormal cerebrospinal fluid flow "any anomaly in the dynamic process by which CSF circulates from the sites of secretion to the sites of absorption according to a unidirectional rostrocaudal flow in ventricular cavities and a multidirectional flow in subarachnoid spaces; CSF produced by the choroid plexuses in the lateral ventricles travels through interventricular foramina to the third ventricle, and then the fourth ventricle via the cerebral aqueduct and finally to the subarachnoid spaces via the median aperture (foramen of Magendie) of the fourth ventricle; in the cranial subarachnoid space, CSF circulates rostrally to the villous sites of absorption or caudally to the spinal subarachnoid space; CSF circulation through the ventricular system is driven by motile cilia on ependymal cells of the brain; CSF flow is pulsatile, corresponding to the systolic pulse wave in choroidal arteries; additional factors such as respiratory waves, the subject s posture, jugular venous pressure and physical effort also modulate CSF flow dynamics and pressure" [MGI:Anna, PMID:22100360, PMID:24229449]
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Allelic Composition: Cd79am1Btlr/Cd79am1Btlr
Genetic Background: involves: C57BL/6J * C57BL/10J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr