ENSMUSG00000027698


Mus musculus

Features
Gene ID: ENSMUSG00000027698
  
Biological name :Nceh1
  
Synonyms : Nceh1 / Neutral cholesterol ester hydrolase 1 / Q8BLF1
  
Possible biological names infered from orthology : Q6PIU2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 27182965
Gene end: 27284608
  
Corresponding Affymetrix probe sets: 10491083 (MoGene1.0st)   1435134_at (Mouse Genome 430 2.0 Array)   1435135_at (Mouse Genome 430 2.0 Array)   1455227_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115209
Ensembl peptide - ENSMUSP00000045864
Ensembl peptide - ENSMUSP00000088829
NCBI entrez gene - 320024     See in Manteia.
MGI - MGI:2443191
RefSeq - NM_178772
RefSeq - XM_011249684
RefSeq Peptide - NP_848887
swissprot - D6RGP7
swissprot - Q8BLF1
swissprot - Q8BYQ0
Ensembl - ENSMUSG00000027698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR376848.1ENSDARG00000115549Danio rerio
 nceh1aENSDARG00000020427Danio rerio
 nceh1b.1ENSDARG00000062087Danio rerio
 NCEH1ENSGALG00000009170Gallus gallus
 NCEH1ENSG00000144959Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aadac / Q99PG0 / arylacetamide deacetylase / P22760*ENSMUSG0000002776143
Aadacl2 / arylacetamide deacetylase like 2 / Q6P093*ENSMUSG0000009137638
Gm5538ENSMUSG0000009052738
Gm8298ENSMUSG0000009552237
Gm13178 / Q5VUY2* / AADACL4* / arylacetamide deacetylase like 4*ENSMUSG0000004173529
C130079G13Rik / RIKEN cDNA C130079G13 geneENSMUSG0000003695128
A2A7Z8 / Aadacl3 / Arylacetamide deacetylase-like 3 / Q5VUY0*ENSMUSG0000007850728
Gm438 / Q5VUY2* / AADACL4* / arylacetamide deacetylase like 4*ENSMUSG0000007850427
Q8BM81 / 9430007A20Rik / Arylacetamide deacetylase-like 4 / Q5VUY2* / AADACL4*ENSMUSG0000002859327
Gm436 / Q5VUY2* / AADACL4* / arylacetamide deacetylase like 4*ENSMUSG0000007850526
Aadacl4 / arylacetamide deacetylase like 4 / Q5VUY2*ENSMUSG0000007060926
Gm13124 / Q5VUY2* / AADACL4* / arylacetamide deacetylase like 4*ENSMUSG0000007850626


Protein motifs (from Interpro)
Interpro ID Name
 IPR013094  Alpha/beta hydrolase fold-3
 IPR017157  Arylacetamide deacetylase
 IPR029058  Alpha/Beta hydrolase fold
 IPR033140  Lipase, GDXG, putative serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009056 catabolic process IBA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017171 serine hydrolase activity IDA
 molecular_functionGO:0042301 phosphate ion binding IDA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0003193 decreased cholesterol efflux "reduced level of removal of excess cholesterol from cells by an active transport pathway" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Slc34a1tm1Hten/Slc34a1tm1Hten
Genetic Background: B6.129S2-Slc34a1tm1Hten/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129S7-Nceh1tm1Ishi Lipetm1Ishi

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129-Nceh1tm1Ishi Apoetm1Unc

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lipetm1Ishi/Lipetm1Ishi,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Lipetm1Ishi/Lipetm1Ishi,Nceh1tm1Ishi/Nceh1tm1Ishi
Genetic Background: B6.129S7-Nceh1tm1Ishi Lipetm1Ishi

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm2Xu/Trp53tm2Xu,Xrcc4tm1Fwa/Xrcc4tm1Fwa
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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