ENSG00000144959


Homo sapiens

Features
Gene ID: ENSG00000144959
  
Biological name :NCEH1
  
Synonyms : NCEH1 / neutral cholesterol ester hydrolase 1 / Q6PIU2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q26.31
Gene start: 172630249
Gene end: 172711218
  
Corresponding Affymetrix probe sets: 225847_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443227
Ensembl peptide - ENSP00000392934
Ensembl peptide - ENSP00000402196
Ensembl peptide - ENSP00000418571
Ensembl peptide - ENSP00000442464
NCBI entrez gene - 57552     See in Manteia.
OMIM - 613234
RefSeq - NM_020792
RefSeq - NM_001146276
RefSeq - NM_001146277
RefSeq - NM_001146278
RefSeq Peptide - NP_001139748
RefSeq Peptide - NP_065843
RefSeq Peptide - NP_001139750
RefSeq Peptide - NP_001139749
swissprot - Q6PIU2
swissprot - A0A0A0MTJ9
swissprot - A0A0R4J2G3
swissprot - F8WE33
swissprot - H7C046
Ensembl - ENSG00000144959
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR376848.1ENSDARG00000115549Danio rerio
 nceh1aENSDARG00000020427Danio rerio
 nceh1b.1ENSDARG00000062087Danio rerio
 NCEH1ENSGALG00000009170Gallus gallus
 Nceh1ENSMUSG00000027698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AADAC / P22760 / arylacetamide deacetylaseENSG0000011477139
Q6P093 / AADACL2 / arylacetamide deacetylase like 2ENSG0000019795335
Q5VUY2 / AADACL4 / arylacetamide deacetylase like 4ENSG0000020451826
Q5VUY0 / AADACL3 / arylacetamide deacetylase like 3ENSG0000018898425


Protein motifs (from Interpro)
Interpro ID Name
 IPR002168  Lipase, GDXG, putative histidine active site
 IPR013094  Alpha/beta hydrolase fold-3
 IPR017157  Arylacetamide deacetylase
 IPR029058  Alpha/Beta hydrolase fold
 IPR033140  Lipase, GDXG, putative serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009056 catabolic process IBA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0034383 low-density lipoprotein particle clearance TAS
 biological_processGO:0060395 SMAD protein signal transduction IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004771 sterol esterase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017171 serine hydrolase activity IBA
 molecular_functionGO:0042301 phosphate ion binding IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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