| MP:0001916 | intracerebral hemorrhage | "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0004613 | fusion of vertebral arches | "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0005018 | decreased T cell number | "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0006063 | abnormal inferior vena cava morphology | "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0008040 | decreased NK T cell number | "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0008097 | increased plasma cell number | "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0008173 | increased follicular B cell number | "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0008182 | decreased marginal zone B cell number | "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0009820 | abnormal liver vasculature morphology | "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0010420 | muscular ventricular septal defect | "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0010490 | abnormal inferior vena cava valve morphology | "any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0010851 | decreased effector memory CD8-positive, alpha-beta T cell number | "reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0011683 | dual inferior vena cava | "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013022 | increased Ly6C high monocyte number | "increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013433 | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | "increase in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013435 | decreased CD8-positive, naive alpha-beta T cell number | "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013511 | increased CD4-negative NK T cell number | "increase in the number of CD4-negative NK T cells" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013519 | decreased CD4-positive NK T cell number | "reduction in the number of CD4-positive NK T cells" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013522 | decreased memory-marker CD4-positive NK T cell number | "reduction in the number of memory-marker CD4-positive NK T cells with a CD44+ CD62L- phenotype" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013669 | decreased Ly6C-positive immature NK cell number | "reduction in the number of immature NK cells expressing the memory marker Ly6C" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013675 | decreased Ly6C-positive mature NK cell number | "reduction in the number of mature NK cells expressing the memory marker Ly6C" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013692 | increased CD5-positive Ly6C-positive T cell number | "increase in the number of CD5-positive T cells expressing the memory marker Ly6C" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013768 | decreased marginal zone precursor B cell number | "reduction in the number of CD23-positive, CD21-positive B cells in the marginal zone of lymphoid tissues" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013772 | increased effector memory T-helper cell number | "increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013775 | increased KLRG1-positive T-helper cell number | "increase in the number of CD4-positive alpha-beta T-helper cells expressing KLRG1, a marker associated with activation" [MGI:Saran] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013834 | thin hypoglossal nerve | "slender appearance of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013859 | abnormal vitelline vein connection | "aberrant or missing attachment of the paired veins that carry blood from the yolk sac back to the embryo" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013877 | abnormal ductus venosus valve morphology | "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0013975 | abnormal coronary sinus connection | |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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| MP:0014001 | abnormal vertebral artery topology | "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith] |
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay
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