ENSMUSG00000027778


Mus musculus

Features
Gene ID: ENSMUSG00000027778
  
Biological name :Ift80
  
Synonyms : Ift80 / Intraflagellar transport / Q8K057
  
Possible biological names infered from orthology : AC079594.2 / intraflagellar transport 80 / Q9P2H3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E1
Gene start: 68892499
Gene end: 69004570
  
Corresponding Affymetrix probe sets: 10498599 (MoGene1.0st)   1427568_a_at (Mouse Genome 430 2.0 Array)   1428329_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118406
Ensembl peptide - ENSMUSP00000133263
Ensembl peptide - ENSMUSP00000122919
Ensembl peptide - ENSMUSP00000029347
Ensembl peptide - ENSMUSP00000103442
NCBI entrez gene - 68259     See in Manteia.
MGI - MGI:1915509
RefSeq - XM_006501966
RefSeq - XM_017319702
RefSeq - NM_026641
RefSeq - XM_006501967
RefSeq Peptide - NP_080917
swissprot - Q8K057
swissprot - D3Z157
swissprot - D3YWI8
Ensembl - ENSMUSG00000027778
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ift80ENSDARG00000038879Danio rerio
 ENSGALG00000009559Gallus gallus
 AC079594.2ENSG00000248710Homo sapiens
 IFT80ENSG00000068885Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0042073 intraciliary transport IC
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:1905515 non-motile cilium assembly IMP
 biological_processGO:2000051 negative regulation of non-canonical Wnt signaling pathway IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium TAS
 cellular_componentGO:0030992 intraciliary transport particle B IDA
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cd44tm1Mak/Cd44+
Genetic Background: B6.129P2-Cd44tm1Mak Apoetm1Unc

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0013206 abnormal motile cilium morphology "any structural anomaly of a cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues and may also function as sensory organelles" [GO:0031514]
Show

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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