Manteia

ENSMUSG00000027809

Mus musculus

Features

Gene ID:	ENSMUSG00000027809

Biological name :	Etfdh

Synonyms :	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial / Etfdh / Q921G7

Possible biological names infered from orthology :	electron transfer flavoprotein dehydrogenase / Q16134

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	E3
Gene start:	79603788
Gene end:	79629500

Corresponding Affymetrix probe sets:	10498837 (MoGene1.0st) 1451084_at (Mouse Genome 430 2.0 Array) 1458152_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000029386 Ensembl peptide - ENSMUSP00000113888 NCBI entrez gene - 66841 See in Manteia. MGI - MGI:106100 RefSeq - NM_025794 RefSeq Peptide - NP_080070 swissprot - Q6PF96 swissprot - Q921G7 Ensembl - ENSMUSG00000027809

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
etfdh	ENSDARG00000038834	Danio rerio
ETFDH	ENSGALG00000009442	Gallus gallus
ETFDH	ENSG00000171503	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000103	Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
IPR036188	FAD/NAD(P)-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006979	response to oxidative stress	IDA
biological_process	GO:0022900	electron transport chain	IEA
biological_process	GO:0022904	respiratory electron transport chain	IEA
biological_process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005743	mitochondrial inner membrane	IDA
cellular_component	GO:0016020	membrane	ISS
cellular_component	GO:0017133	mitochondrial electron transfer flavoprotein complex	TAS
cellular_component	GO:0031305	integral component of mitochondrial inner membrane	IEA
cellular_component	GO:0031966	mitochondrial membrane	IEA
molecular_function	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	IBA
molecular_function	GO:0009055	electron transfer activity	IEA
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0043783	oxidoreductase activity, oxidizing metal ions with flavin as acceptor	IBA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0048038	quinone binding	IEA
molecular_function	GO:0048039	ubiquinone binding	IEA
molecular_function	GO:0051536	iron-sulfur cluster binding	IEA
molecular_function	GO:0051539	4 iron, 4 sulfur cluster binding	IBA

Pathways (from Reactome)

Pathway description

Respiratory electron transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Epb41^{tm1b(KOMP)Mbp}/Epb41⁺ Genetic Background: C57BL/6N-Epb41^{tm1b(KOMP)Mbp}/J
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Epb41^{tm1b(KOMP)Mbp}/Epb41⁺ Genetic Background: C57BL/6N-Epb41^{tm1b(KOMP)Mbp}/J
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Epb41^{tm1b(KOMP)Mbp}/Epb41⁺ Genetic Background: C57BL/6N-Epb41^{tm1b(KOMP)Mbp}/J
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Epb41^{tm1b(KOMP)Mbp}/Epb41⁺ Genetic Background: C57BL/6N-Epb41^{tm1b(KOMP)Mbp}/J
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Epb41^{tm1b(KOMP)Mbp}/Epb41⁺ Genetic Background: C57BL/6N-Epb41^{tm1b(KOMP)Mbp}/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000032314	Etfa / Q99LC5 / Electron transfer flavoprotein subunit alpha, mitochondrial / P13804* / electron transfer flavoprotein alpha subunit*	/ reaction
ENSMUSG00000004610	Etfb / Q9DCW4 / Electron transfer flavoprotein subunit beta / P38117* / electron transfer flavoprotein beta subunit*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr