| MP:0000219 | increased neutrophil count | "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
|
| MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0000781 | reduced size of corpus callosum | "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001194 | dermatitis | "inflammation of the skin" [J:65146] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001828 | abnormal T cell activation | "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001847 | brain inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001852 | conjunctivitis | "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001870 | salivary gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001873 | stomach inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0001973 | increased thermal nociceptive threshold | "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0002032 | sarcoma | "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0002048 | lung adenoma | "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0002406 | increased susceptibility to infection | "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0003224 | neuron degeneration | "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0003608 | prostate inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the prostate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0005014 | increased B cell number | "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0005405 | axon degeneration | "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008027 | abnormal spinal cord white matter morphology | "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008614 | increased circulating interleukin-17 level | "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008635 | increased circulating interleukin-18 level | "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008681 | increased interleukin-17 secretion | "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008699 | increased interleukin-4 secretion | "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0009646 | urinary bladder inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0010210 | abnormal circulating cytokine level | "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0012712 | spinal cord degeneration | "a retrogressive impairment of function or destruction of the spinal cord" [MGI:anna] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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| MP:0013905 | preputial gland inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in any of the paired, lobulated, modified sebaceous glands located in the inguinal region adjacent to the penis and vagina, with pheromonal functions in male rodents; in males, the preputial gland empties into the preputial cavity and in females, the preputial (aka clitoral) gland duct empties into the clitoral fossa" [MGI:Anna] |
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Allelic Composition: Zfhx3Sci/Zfhx3Sci
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J
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