ENSMUSG00000028048


Mus musculus

Features
Gene ID: ENSMUSG00000028048
  
Biological name :Gba
  
Synonyms : Gba / Glucosylceramidase / P17439
  
Possible biological names infered from orthology : glucosylceramidase beta / P04062
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 89202928
Gene end: 89208966
  
Corresponding Affymetrix probe sets: 10493435 (MoGene1.0st)   1437044_a_at (Mouse Genome 430 2.0 Array)   1450099_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076589
Ensembl peptide - ENSMUSP00000130660
Ensembl peptide - ENSMUSP00000142401
NCBI entrez gene - 14466     See in Manteia.
MGI - MGI:95665
RefSeq - XM_006500998
RefSeq - NM_001077411
RefSeq - NM_008094
RefSeq - XM_006500997
RefSeq Peptide - NP_032120
RefSeq Peptide - NP_001070879
swissprot - P17439
swissprot - A0A0G2JDK2
Ensembl - ENSMUSG00000028048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gbaENSDARG00000076058Danio rerio
 GBAENSG00000177628Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001139  Glycoside hydrolase family 30
 IPR017853  Glycoside hydrolase superfamily
 IPR033452  Glycosyl hydrolase family 30, beta sandwich domain
 IPR033453  Glycosyl hydrolase family 30, TIM-barrel domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006680 glucosylceramide catabolic process IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0023021 termination of signal transduction IEA
 biological_processGO:0032268 regulation of cellular protein metabolic process IEA
 biological_processGO:0032269 negative regulation of cellular protein metabolic process IMP
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032463 negative regulation of protein homooligomerization IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0033561 regulation of water loss via skin IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0043243 positive regulation of protein complex disassembly IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043589 skin morphogenesis IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0046512 sphingosine biosynthetic process IEA
 biological_processGO:0046513 ceramide biosynthetic process IEA
 biological_processGO:0051246 regulation of protein metabolic process IMP
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901805 beta-glucoside catabolic process IEA
 biological_processGO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process IMP
 biological_processGO:1903061 positive regulation of protein lipidation IEA
 biological_processGO:1904457 positive regulation of neuronal action potential IEA
 biological_processGO:1904925 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IMP
 biological_processGO:1905037 autophagosome organization IMP
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043202 lysosomal lumen IDA
 molecular_functionGO:0004348 glucosylceramidase activity IMP
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005124 scavenger receptor binding IEA
 molecular_functionGO:0016787 hydrolase activity IDA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nacatm1Dsr/Nacatm1Dsr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Spasttm1.1Jme/Spast+
Genetic Background: involves: C57BL/6J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm1Ggb/Gbatm1Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm3Ggb/Gbatm3Ggb
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Gbatm3Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm4Ggb/Gbatm4Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm4Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Gbatm1Ggb/Gbatm1Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm3Ggb/Gbatm3Ggb
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Gbatm3Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm4Ggb/Gbatm4Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm4Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gbatm1.1Clk/Gbatm1.1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gbatm2Karl/Gbatm2Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gbatm1Ggb/Gbatm1Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm1.1Clk/Gbatm1.1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nacatm1Dsr/Nacatm1Dsr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nacatm1Dsr/Nacatm1Dsr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Gbatm3Ggb/Gbatm3Ggb
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-sh/KitW-sh
Genetic Background: involves: 101/H * C3H/HeH * CBA

 MP:0002295 abnormal pulmonary circulation "anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbatm1Ggb/Gbatm1Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm2Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm3Ggb/Gbatm3Ggb
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Gbatm3Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm4Ggb/Gbatm4Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Gbatm4Ggb/Gbatm1Nsb
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gbatm2Ggb/Gbatm2Ggb,Psaptm1Suz/Psaptm1Suz
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gbatm1Karl/Gbatm1Karl,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Gbatm1.1Eginn/Gbatm1.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003653 decreased skin turgor "reduced ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gbatm1Ggb/Gbatm1Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gbatm1.1Eginn/Gbatm1.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * PL/J

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Gbatm1.1Karl/Gba+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gbatm1Clk/Gbatm1.1Clk,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gbatm1.1Eginn/Gbatm1.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm1Karl/Gbatm1.1Karl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm1.1Eginn/Gbatm1.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008608 increased circulating interleukin-13 level "increase in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008623 increased circulating interleukin-3 level "increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008629 increased circulating interleukin-9 level "increase in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008639 decreased circulating interleukin-1 alpha level "reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Msr1tm1Csk/Msr1tm1Csk
Genetic Background: either: (involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * ICR) or (involves: 129P2/OlaHsd * 129X1/SvJ * 129/Sv * ICR)

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0009974 decreased cerebral cortex pyramidal cell number "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gbatm2Karl/Gbatm2Karl,Tg(KRT14-cre)8Brn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Naglutm1Efn/Naglutm1Efn
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Gbatm2Rlp/Gbatm2Rlp
Genetic Background: involves: 129S4/SvJae

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gbatm1.1Karl/Gbatm1.1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gbatm1.1Clk/Gbatm1.1Clk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gbatm2Karl/Gbatm2Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gbatm1Ggb/Gbatm1Ggb
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Myh6tm1Rbns/Myh6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Gbatm1.1Pmis/Gbatm1.1Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gbatm1.1Pmis/Gbatm1.2Pmis,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004207 Psap / Q61207 / prosaposin / P07602*  / complex






 

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The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr