Manteia - Molecule gene

ENSMUSG00000004207

Mus musculus

Features

Gene ID:	ENSMUSG00000004207

Biological name :	Psap

Synonyms :	prosaposin / Psap / Q61207

Possible biological names infered from orthology :	P07602

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	B4
Gene start:	60277627
Gene end:	60302597

Corresponding Affymetrix probe sets:	10363430 (MoGene1.0st) 10338472 (MoGene1.0st) 10338504 (MoGene1.0st) 10338585 (MoGene1.0st) 10338673 (MoGene1.0st) 10339447 (MoGene1.0st) 10339787 (MoGene1.0st) 10339936 (MoGene1.0st) 10340025 (MoGene1.0st) 10340177 (MoGene1.0st) 10341115 (MoGene1.0st) 10341637 (MoGene1.0st) 10342170 (MoGene1.0st) 10342261 (MoGene1.0st) 10343739 (MoGene1.0st) 10344011 (MoGene1.0st) 10344017 (MoGene1.0st) 10344141 (MoGene1.0st) 1415687_a_at (Mouse Genome 430 2.0 Array) 1421813_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000101105 Ensembl peptide - ENSMUSP00000137286 Ensembl peptide - ENSMUSP00000137476 Ensembl peptide - ENSMUSP00000004316 Ensembl peptide - ENSMUSP00000126407 NCBI entrez gene - 19156 See in Manteia. MGI - MGI:97783 RefSeq - XM_017313849 RefSeq - NM_001146120 RefSeq - NM_001146121 RefSeq - NM_001146122 RefSeq - NM_001146123 RefSeq - NM_001146124 RefSeq - NM_011179 RefSeq - XM_017313848 RefSeq Peptide - NP_001139593 RefSeq Peptide - NP_001139596 RefSeq Peptide - NP_035309 RefSeq Peptide - NP_001139594 RefSeq Peptide - NP_001139595 RefSeq Peptide - NP_001139592 swissprot - Q8BFQ1 swissprot - K3W4L3 swissprot - J3QPG5 swissprot - Q3UFE8 swissprot - Q61207 swissprot - E9PZ00 Ensembl - ENSMUSG00000004207

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
psap	ENSDARG00000013968	Danio rerio
	ENSGALG00000004747	Gallus gallus
PSAP	ENSGALG00000004769	Gallus gallus
PSAP	ENSG00000197746	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Psapl1 / prosaposin-like 1 / Q6NUJ1* / prosaposin like 1 (gene/pseudogene)*	ENSMUSG00000043430	33
Sftpb / surfactant associated protein B / P07988* / surfactant protein B*	ENSMUSG00000056370	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR003119	Saposin A-type domain
IPR007856	Saposin-like type B, region 1
IPR008138	Saposin B type, region 2
IPR008139	Saposin B type domain
IPR008373	Saposin
IPR011001	Saposin-like
IPR021165	Saposin, chordata

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006665	sphingolipid metabolic process	IEA
biological_process	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IDA
biological_process	GO:0019216	regulation of lipid metabolic process	IMP
biological_process	GO:0043085	positive regulation of catalytic activity	IEA
biological_process	GO:0043408	regulation of MAPK cascade	IMP
biological_process	GO:0043410	positive regulation of MAPK cascade	IDA
biological_process	GO:0048589	developmental growth	IMP
biological_process	GO:0060736	prostate gland growth	IMP
biological_process	GO:0060742	epithelial cell differentiation involved in prostate gland development	IMP
biological_process	GO:0071310	cellular response to organic substance	IMP
biological_process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	IDA
biological_process	GO:1905572	ganglioside GM1 transport to membrane	ISO
cellular_component	GO:0005576	extracellular region	ISO
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005764	lysosome	IEA
cellular_component	GO:0031012	extracellular matrix	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0001664	G-protein coupled receptor binding	IPI
molecular_function	GO:0004565	beta-galactosidase activity	IEA
molecular_function	GO:0005543	phospholipid binding	IEA
molecular_function	GO:0008047	enzyme activator activity	IBA
molecular_function	GO:0042802	identical protein binding	ISO
molecular_function	GO:0042803	protein homodimerization activity	IEA
molecular_function	GO:1905573	ganglioside GM1 binding	ISO
molecular_function	GO:1905574	ganglioside GM2 binding	ISO
molecular_function	GO:1905575	ganglioside GM3 binding	ISO
molecular_function	GO:1905576	ganglioside GT1b binding	ISO
molecular_function	GO:1905577	ganglioside GP1c binding	ISO

Pathways (from Reactome)

Pathway description

Platelet degranulation

Glycosphingolipid metabolism

Peptide ligand-binding receptors

G alpha (i) signalling events

Neutrophil degranulation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) Allelic Composition: Psap^tm1Suz/Psap⁺ Genetic Background: involves: 129P2/OlaHsd * FVB
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000436	abnormal head movements	"anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000521	abnormal kidney cortex	"anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000748	progressive muscle weakness	"increasing loss of strength over time" [MGI:CLS, J:67994]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000787	abnormal telencephalon morphology	"any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000820	abnormal choroid plexus morphology	"malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000876	Purkinje cell degeneration	"a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: FVB.129S-Psap^tm1Juma
MP:0000921	demyelination	"loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001045	abnormal enteric ganglia morphology	"any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0001106	abnormal Schwann cell	"malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0001158	abnormal prostate morphology	"mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0001168	prostate epithelial dysplasia	"abnormal development of the prostate epithelium" [J:63764]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Hif1a^tm3Rsjo/Hif1a^tm3Rsjo,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001392	abnormal locomotor activity	"altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0001407	short stride length	"reduced average distance between steps" [J:34193]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001426	polydipsia	"excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001473	reduced long term potentiation	"less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]	Show Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001524	impaired limb coordination	"reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]	Show Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: B6.129P2-Psap^tm1Suz
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aqp2^tm1(cre)Blyg/Aqp2^tm1(cre)Blyg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0002059	abnormal seminal gland morphology	"anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002064	seizures	"sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: FVB.129S-Psap^tm1Juma Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: B6.129P2-Psap^tm1Suz Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002133	abnormal respiratory system physiology	"anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppif^tm1Tsu/Ppif^tm1Tsu Genetic Background: involves: 129S5/SvEvBrd
MP:0002182	abnormal astrocyte morphology	"anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002184	abnormal innervation	"the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002269	muscular atrophy	"a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002446	abnormal macrophage morphology	"anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002574	increased vertical activity	"greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002631	abnormal epididymis morphology	"malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002703	abnormal renal tubules	"anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002730	head shaking	"compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002809	enlarged spinal cord size	"larger appearance of the spinal cord" [J:83935]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002826	tonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0003224	neuron degeneration	"a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Gba^tm2Ggb/Gba^tm2Ggb,Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd
MP:0003289	abnormal intestinal peristalsis	"altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003329	amyloid beta deposits		Show Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0003382	straub tail	"condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0003492	abnormal involuntary movement	"anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0003691	abnormal microglial cell function	"anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: FVB.129S-Psap^tm1Juma
MP:0003871	abnormal myelin sheath morphology	"malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0003993	abnormal ventral spinal root morphology	"any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004087	abnormal muscle fiber morphology	"malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0004191	neuronal intranuclear inclusions	"presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0004302	abnormal Dieters cell morphology	"any structural abnormality in the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004393	abnormal cochlear inner hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004404	cochlear outer hair cell degeneration	"degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004434	abnormal cochlear outer hair cell physiology	"anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004632	abnormal cochlear OHC efferent innervation	"any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004633	abnormal cochlear IHC efferent innervation	"any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004736	abnormal distortion product otoacoustic emission	"any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004740	sensorineural hearing loss	"a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004746	abnormal cochlear IHC afferent innervation	"any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear IHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)
MP:0004757	abnormal distal convoluted tubule morphology	"any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0004811	abnormal neuron physiology	"anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0004901	decreased male germ cell number	"reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0004910	decreased seminal gland weight	"reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0004929	decreased epididymis weight	"reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0004962	decreased prostate weight	"reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0005180	abnormal circulating testosterone level	"aberration in the blood concentration of this most potent androgen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0005277	abnormal brainstem morphology	"anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Juma/Psap^tm1Juma Genetic Background: FVB.129S-Psap^tm1Juma
MP:0005300	abnormal corneal stroma morphology	"structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0005302	neurogenic bladder	"defective functioning of the bladder due to impaired innervation, either within the CNS or the PNS" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0005405	axon degeneration	"retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm1Ggb/Psap^tm1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0006055	abnormal vascular endothelial cell morphology	"malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0006082	CNS inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0008026	abnormal brain white matter morphology	"any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0008260	abnormal autophagy	"abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0008285	abnormal hippocampus granule cell layer		Show Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0009434	paraparesis	"a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psap^tm2Ggb/Psap^tm2Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0010047	axonal spheroids	"focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm3.1Ggb/Psap^tm3.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0011083	complete lethality at weaning	"premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Psap^tm1Suz/Psap^tm1Suz Genetic Background: B6.129P2-Psap^tm1Suz
MP:0011617	abnormal habituation	"anomaly in the process in which there is a progressive decline of behavioral response probability with a repetitive stimulus" [GO:0046959, PMID:16774787]	Show Allelic Composition: Crabp1^tm1Ipc/Crabp1^tm1Ipc Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Psap^tm4.1Ggb/Psap^tm4.1Ggb Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: En1^tm1Alj/En1^tm1Alj,Wnt7a^tm1Amc/Wnt7a^tm1Amc,Tg(Wnt1-En1)1Amc/0 Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000028048	Gba / P17439 / Glucosylceramidase / P04062* / glucosylceramidase beta*	/ complex
ENSMUSG00000026424	Q99JG2 / Gpr37l1 / G protein-coupled receptor 37-like 1 / O60883*	/ complex / reaction
ENSMUSG00000039904	Gpr37 / Q9QY42 / Prosaposin receptor GPR37 / O15354* / G protein-coupled receptor 37*	/ complex / reaction

0 s.

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