ENSMUSG00000039904


Mus musculus

Features
Gene ID: ENSMUSG00000039904
  
Biological name :Gpr37
  
Synonyms : Gpr37 / Prosaposin receptor GPR37 / Q9QY42
  
Possible biological names infered from orthology : G protein-coupled receptor 37 / O15354
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.1
Gene start: 25665878
Gene end: 25690729
  
Corresponding Affymetrix probe sets: 10543466 (MoGene1.0st)   1450875_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052185
Ensembl peptide - ENSMUSP00000144683
NCBI entrez gene - 14763     See in Manteia.
MGI - MGI:1313297
RefSeq - NM_010338
RefSeq Peptide - NP_034468
swissprot - Q9QY42
Ensembl - ENSMUSG00000039904
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr37aENSDARG00000074563Danio rerio
 gpr37bENSDARG00000033296Danio rerio
 GPR37ENSGALG00000040954Gallus gallus
 GPR37ENSG00000170775Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99JG2 / Gpr37l1 / G protein-coupled receptor 37-like 1 / O60883*ENSMUSG0000002642435
Ednrb / P48302 / Endothelin receptor type B / P24530*ENSMUSG0000002212219
Ednra / Q61614 / Endothelin-1 receptor / P25101* / endothelin receptor type A*ENSMUSG0000003161616
Nmbr / O54799 / Neuromedin-B receptor / P28336*ENSMUSG0000001986515
Grpr / P21729 / Gastrin-releasing peptide receptor / P30550*ENSMUSG0000003136415
Brs3 / O54798 / Bombesin receptor subtype-3 / P32247*ENSMUSG0000003113014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003909  G protein-coupled receptor 37 orphan
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0031987 locomotion involved in locomotory behavior IMP
 biological_processGO:0042416 dopamine biosynthetic process IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045964 positive regulation of dopamine metabolic process IMP
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0036505 prosaposin receptor activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000836 abnormal substantia nigra morphology "malformation or absence of the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Gpr37tm1.1Ryot/Gpr37tm1.1Ryot
Genetic Background: involves: C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpr37tm1.1Ryot/Gpr37tm1.1Ryot
Genetic Background: involves: C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gpr37tm1.1Ryot/Gpr37tm1.1Ryot
Genetic Background: involves: C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpr37tm1.1Ryot/Gpr37tm1.1Ryot
Genetic Background: involves: C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gpr37tm1.1Ryot/Gpr37tm1.1Ryot
Genetic Background: involves: C57BL/6

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

Allelic Composition: Gpr37tm1.1Ryot/Gpr37tm1.1Ryot
Genetic Background: involves: C57BL/6

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Gpr37tm1.1Ryot/Gpr37tm1.1Ryot
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004207 Psap / Q61207 / prosaposin / P07602*  / complex / reaction






 

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