ENSMUSG00000031130


Mus musculus

Features
Gene ID: ENSMUSG00000031130
  
Biological name :Brs3
  
Synonyms : Bombesin receptor subtype-3 / Brs3 / O54798
  
Possible biological names infered from orthology : P32247
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A6
Gene start: 57043074
Gene end: 57048758
  
Corresponding Affymetrix probe sets: 10599776 (MoGene1.0st)   1422265_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033464
NCBI entrez gene - 12209     See in Manteia.
MGI - MGI:1100501
RefSeq - NM_009766
RefSeq Peptide - NP_033896
swissprot - O54798
Ensembl - ENSMUSG00000031130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BRS3ENSGALG00000006406Gallus gallus
 BRS3ENSG00000102239Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grpr / P21729 / Gastrin-releasing peptide receptor / P30550*ENSMUSG0000003136447
Nmbr / O54799 / Neuromedin-B receptor / P28336*ENSMUSG0000001986545
Ednrb / P48302 / Endothelin receptor type B / P24530*ENSMUSG0000002212229
Ednra / Q61614 / Endothelin-1 receptor / P25101* / endothelin receptor type A*ENSMUSG0000003161627
Gpr37 / Q9QY42 / Prosaposin receptor GPR37 / O15354* / G protein-coupled receptor 37*ENSMUSG0000003990421
Q99JG2 / Gpr37l1 / G protein-coupled receptor 37-like 1 / O60883*ENSMUSG0000002642419


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001556  Bombesin receptor-like
 IPR001560  Bombesin receptor type 3
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0031989 bombesin receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004946 bombesin receptor activity IEA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: LeprDb-2Btlr/LeprDb-2Btlr
Genetic Background: C57BL/6J-LeprDb-2Btlr

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Brs3tm1Jfb/Brs3tm1Jfb
Genetic Background: B6.129X1-Brs3tm1Jfb

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Brs3tm1Jfb/Brs3tm1Jfb
Genetic Background: B6.129X1-Brs3tm1Jfb

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Brs3tm1Jfb/Brs3tm1Jfb
Genetic Background: B6.129X1-Brs3tm1Jfb

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Brs3tm1Jfb/Brs3tm1Jfb
Genetic Background: B6.129X1-Brs3tm1Jfb

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpamtm1Lex/Gpamtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

Allelic Composition: Brs3tm1Jfb/Brs3tm1Jfb
Genetic Background: B6.129X1-Brs3tm1Jfb

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brs3tm1Jfb/Brs3tm1Jfb
Genetic Background: B6.129X1-Brs3tm1Jfb

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Brs3tm1Jfb/Brs3tm1Jfb
Genetic Background: B6.129X1-Brs3tm1Jfb

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Gdf5brp/Gdf5brp
Genetic Background: NC

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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