ENSG00000170775


Homo sapiens

Features
Gene ID: ENSG00000170775
  
Biological name :GPR37
  
Synonyms : GPR37 / G protein-coupled receptor 37 / O15354
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q31.33
Gene start: 124745997
Gene end: 124765627
  
Corresponding Affymetrix probe sets: 209631_s_at (Human Genome U133 Plus 2.0 Array)   214586_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306449
NCBI entrez gene - 2861     See in Manteia.
OMIM - 602583
RefSeq - NM_005302
RefSeq Peptide - NP_005293
swissprot - O15354
Ensembl - ENSG00000170775
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr37aENSDARG00000074563Danio rerio
 gpr37bENSDARG00000033296Danio rerio
 GPR37ENSGALG00000040954Gallus gallus
 Gpr37ENSMUSG00000039904Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60883 / GPR37L1 / G protein-coupled receptor 37 like 1ENSG0000017007537
EDNRB / P24530 / endothelin receptor type BENSG0000013616018
EDNRA / P25101 / endothelin receptor type AENSG0000015161716
NMBR / P28336 / neuromedin B receptorENSG0000013557715
GRPR / P30550 / gastrin releasing peptide receptorENSG0000012601015
BRS3 / P32247 / bombesin receptor subtype 3ENSG0000010223913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003909  G protein-coupled receptor 37 orphan
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0031987 locomotion involved in locomotory behavior IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045964 positive regulation of dopamine metabolic process IEA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death ISS
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IDA
 molecular_functionGO:0030544 Hsp70 protein binding IPI
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0036505 prosaposin receptor activity IDA
 molecular_functionGO:0042277 peptide binding IPI


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000197746 PSAP / P07602 / prosaposin  / reaction / complex






 

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