ENSMUSG00000028088


Mus musculus

Features
Gene ID: ENSMUSG00000028088
  
Biological name :Fmo5
  
Synonyms : Fmo5 / Mus musculus flavin containing monooxygenase 5 (Fmo5), transcript variant 4, mRNA. / P97872
  
Possible biological names infered from orthology : flavin containing monooxygenase 5 / P49326
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 97628804
Gene end: 97655282
  
Corresponding Affymetrix probe sets: 10494565 (MoGene1.0st)   1421709_a_at (Mouse Genome 430 2.0 Array)   1440899_at (Mouse Genome 430 2.0 Array)   1450332_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029729
Ensembl peptide - ENSMUSP00000102664
Ensembl peptide - ENSMUSP00000102665
NCBI entrez gene - 14263     See in Manteia.
MGI - MGI:1310004
RefSeq - XM_017319455
RefSeq - NM_001161763
RefSeq - NM_001161765
RefSeq - NM_001355119
RefSeq - NM_010232
RefSeq - XM_006500995
RefSeq - XM_006500996
RefSeq - XM_011240013
RefSeq Peptide - NP_001155235
RefSeq Peptide - NP_001155237
RefSeq Peptide - NP_001342048
RefSeq Peptide - NP_034362
swissprot - P97872
Ensembl - ENSMUSG00000028088
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fmo5ENSDARG00000016357Danio rerio
 si:dkey-239i20.2ENSDARG00000043518Danio rerio
 si:dkey-239i20.4ENSDARG00000043514Danio rerio
 ENSGALG00000003022Gallus gallus
 ENSGALG00000001723Gallus gallus
 FMO5ENSG00000131781Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fmo9 / flavin containing monooxygenase 9 isoform 2 ENSMUSG0000002656062
Gm4846ENSMUSG0000008605657
Gm4847ENSMUSG0000005108156
Fmo2 / Q8K2I3 / Dimethylaniline monooxygenase [N-oxide-forming] 2 / Q99518* / flavin containing monooxygenase 2*ENSMUSG0000004017055
Fmo3 / P97501 / Dimethylaniline monooxygenase [N-oxide-forming] 3 / P31513* / flavin containing monooxygenase 3*ENSMUSG0000002669153
Fmo6ENSMUSG0000009557651
Fmo4 / Q8VHG0 / Dimethylaniline monooxygenase [N-oxide-forming] 4 / P31512* / flavin containing monooxygenase 4*ENSMUSG0000002669249
Fmo1 / P50285 / Mus musculus flavin containing monooxygenase 1 (Fmo1), transcript variant 3, mRNA. / Q01740* / flavin containing monooxygenase 1*ENSMUSG0000004018149


Protein motifs (from Interpro)
Interpro ID Name
 IPR000960  Flavin monooxygenase FMO
 IPR002257  Flavin monooxygenase (FMO) 5
 IPR020946  Flavin monooxygenase-like
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0004499 N,N-dimethylaniline monooxygenase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0050661 NADP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0013243 abnormal carbohydrate metabolism "any anomaly in the chemical reactions and pathways involving a carbohydrate, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0013245 abnormal lipid metabolism "any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes" [MPD:Molly]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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