ENSMUSG00000028108


Mus musculus

Features
Gene ID: ENSMUSG00000028108
  
Biological name :Ecm1
  
Synonyms : Ecm1 / Mus musculus extracellular matrix protein 1 (Ecm1), transcript variant 3, mRNA. / Q61508
  
Possible biological names infered from orthology : extracellular matrix protein 1 / Q16610
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 95734147
Gene end: 95739569
  
Corresponding Affymetrix probe sets: 10500204 (MoGene1.0st)   1448613_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114659
Ensembl peptide - ENSMUSP00000112665
Ensembl peptide - ENSMUSP00000114747
Ensembl peptide - ENSMUSP00000122243
Ensembl peptide - ENSMUSP00000120820
Ensembl peptide - ENSMUSP00000120300
Ensembl peptide - ENSMUSP00000115524
Ensembl peptide - ENSMUSP00000029753
NCBI entrez gene - 13601     See in Manteia.
MGI - MGI:103060
RefSeq - XM_017319450
RefSeq - NM_001252653
RefSeq - NM_001355070
RefSeq - NM_007899
RefSeq - XM_006500984
RefSeq - XM_006500985
RefSeq - XM_011240008
RefSeq - XM_011240009
RefSeq - XM_017319449
RefSeq Peptide - NP_001341999
RefSeq Peptide - NP_031925
RefSeq Peptide - NP_001239582
swissprot - D3Z038
swissprot - D3YZV0
swissprot - F8WI14
swissprot - D3YV64
swissprot - D3YV22
swissprot - Q61508
swissprot - D3Z772
swissprot - D3Z0U9
Ensembl - ENSMUSG00000028108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ecm1aENSDARG00000100535Danio rerio
 ecm1bENSDARG00000105239Danio rerio
 ECM1ENSG00000143369Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008605  Extracellular matrix protein 1
 IPR020858  Serum albumin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001960 negative regulation of cytokine-mediated signaling pathway IDA
 biological_processGO:0002828 regulation of type 2 immune response IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0031214 biomineral tissue development IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:2000404 regulation of T cell migration IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005134 interleukin-2 receptor binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0043236 laminin binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129P2/OlaHsd * FVB * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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