ENSMUSG00000028116


Mus musculus

Features
Gene ID: ENSMUSG00000028116
  
Biological name :Myoz2
  
Synonyms : Myoz2 / Myozenin-2 / Q9JJW5
  
Possible biological names infered from orthology : Q9NPC6
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G1
Gene start: 123006206
Gene end: 123035015
  
Corresponding Affymetrix probe sets: 10501895 (MoGene1.0st)   1418769_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029761
Ensembl peptide - ENSMUSP00000115450
NCBI entrez gene - 59006     See in Manteia.
MGI - MGI:1913063
RefSeq - XM_006501830
RefSeq - NM_021503
RefSeq - XM_006501828
RefSeq - XM_006501829
RefSeq Peptide - NP_067478
swissprot - D6RGM5
swissprot - Q9JJW5
Ensembl - ENSMUSG00000028116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO818704.1ENSDARG00000099032Danio rerio
 myoz2aENSDARG00000012311Danio rerio
 myoz2bENSDARG00000037266Danio rerio
 MYOZ2ENSGALG00000011991Gallus gallus
 MYOZ2ENSG00000172399Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myoz1 / Q9JK37 / Myozenin-1 / Q9NP98*ENSMUSG0000006869733
Myoz3 / myozenin 3 / Q8TDC0*ENSMUSG0000004917332


Protein motifs (from Interpro)
Interpro ID Name
 IPR008438  Myozenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030239 myofibril assembly IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0015629 actin cytoskeleton IPI
 cellular_componentGO:0030018 Z disc IEA
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0031433 telethonin binding IEA
 molecular_functionGO:0051373 FATZ binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Myoz2tm1Eno/Myoz2tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myoz2tm1Eno/Myoz2tm1Eno,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aipl1tm1Mad/Aipl1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myoz2tm1Eno/Myoz2+,Tg(Myh6-MYOZ2*I246M)#Ajm/0
Genetic Background: involves: 129/Sv * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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