ENSMUSG00000068697


Mus musculus

Features
Gene ID: ENSMUSG00000068697
  
Biological name :Myoz1
  
Synonyms : Myoz1 / Myozenin-1 / Q9JK37
  
Possible biological names infered from orthology : Q9NP98
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: A3
Gene start: 20649107
Gene end: 20656540
  
Corresponding Affymetrix probe sets: 10417933 (MoGene1.0st)   1448636_at (Mouse Genome 430 2.0 Array)   1460202_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087955
NCBI entrez gene - 59011     See in Manteia.
MGI - MGI:1929471
RefSeq - NM_021508
RefSeq Peptide - NP_067483
swissprot - Q9JK37
Ensembl - ENSMUSG00000068697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myoz1aENSDARG00000056209Danio rerio
 myoz1bENSDARG00000071445Danio rerio
 MYOZ1ENSGALG00000005226Gallus gallus
 MYOZ1ENSG00000177791Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myoz2 / Q9JJW5 / Myozenin-2 / Q9NPC6*ENSMUSG0000002811629
Myoz3 / myozenin 3 / Q8TDC0*ENSMUSG0000004917323


Protein motifs (from Interpro)
Interpro ID Name
 IPR008438  Myozenin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030239 myofibril assembly IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0015629 actin cytoskeleton IPI
 cellular_componentGO:0030018 Z disc IBA
 cellular_componentGO:0031143 pseudopodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031433 telethonin binding IBA
 molecular_functionGO:0051373 FATZ binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mybpc3tm1a(EUCOMM)Hmgu/Mybpc3tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003082 abnormal gastrocnemius morphology "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004142 abnormal muscle tone "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009422 decreased gastrocnemius weight "reduction in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Myh1tm1b(KOMP)Wtsi/Myh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Myh1tm1b(KOMP)Wtsi/J

 MP:0010100 increased cervical vertebrae number "increased number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myoz1tm1a(EUCOMM)Hmgu/Myoz1tm1a(EUCOMM)Hmgu
Genetic Background: Not Specified

 MP:0012107 enhanced exercise endurance "improved performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Hdac3tm1.2Eno/Hdac3tm1.2Eno
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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