ENSMUSG00000028159


Mus musculus

Features
Gene ID: ENSMUSG00000028159
  
Biological name :Dapp1
  
Synonyms : Dapp1 / Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide / Q9QXT1
  
Possible biological names infered from orthology : dual adaptor of phosphotyrosine and 3-phosphoinositides 1 / Q9UN19
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 137931007
Gene end: 137981545
  
Corresponding Affymetrix probe sets: 10502359 (MoGene1.0st)   1421936_at (Mouse Genome 430 2.0 Array)   1421937_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029806
Ensembl peptide - ENSMUSP00000119634
NCBI entrez gene - 26377     See in Manteia.
MGI - MGI:1347063
RefSeq - XM_017319585
RefSeq - NM_001310753
RefSeq - NM_011932
RefSeq Peptide - NP_036062
RefSeq Peptide - NP_001297682
swissprot - Q3TEK6
swissprot - Q3UK44
swissprot - Q9QXT1
Ensembl - ENSMUSG00000028159
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dapp1ENSDARG00000039535Danio rerio
 DAPP1ENSGALG00000043681Gallus gallus
 DAPP1ENSG00000070190Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035843  DAPP1, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IBA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0030165 PDZ domain binding IBA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp14tm1Ktry/Mmp14tm1Ktry
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

Allelic Composition: Dapp1Gt(OST111213)Lex/Dapp1Gt(OST111213)Lex
Genetic Background: B6.Cg-Dapp1Gt(OST111213)Lex

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

Allelic Composition: Dapp1Gt(OST111213)Lex/Dapp1Gt(OST111213)Lex
Genetic Background: B6.Cg-Dapp1Gt(OST111213)Lex

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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