ENSMUSG00000028185


Mus musculus

Features
Gene ID: ENSMUSG00000028185
  
Biological name :Dnase2b
  
Synonyms : Deoxyribonuclease-2-beta / Dnase2b / Q9QY48
  
Possible biological names infered from orthology : Q8WZ79
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H2
Gene start: 146580985
Gene end: 146615596
  
Corresponding Affymetrix probe sets: 10502686 (MoGene1.0st)   1450237_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029836
Ensembl peptide - ENSMUSP00000142872
NCBI entrez gene - 56629     See in Manteia.
MGI - MGI:1913283
RefSeq - XM_011240172
RefSeq - NM_019957
RefSeq - XM_006501764
RefSeq - XM_011240171
RefSeq - XM_006501763
RefSeq Peptide - NP_064341
swissprot - Q9QY48
Ensembl - ENSMUSG00000028185
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnase2bENSDARG00000077918Danio rerio
 DNASE2BENSGALG00000028790Gallus gallus
 Q8WZ79ENSG00000137976Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P56542 / Dnase2a / Deoxyribonuclease-2-alpha / DNASE2* / O00115* / deoxyribonuclease 2, lysosomal*ENSMUSG0000000381236


Protein motifs (from Interpro)
Interpro ID Name
 IPR004947  Deoxyribonuclease II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006309 apoptotic DNA fragmentation IBA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004520 endodeoxyribonuclease activity IDA
 molecular_functionGO:0004531 deoxyribonuclease II activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Cisd2tm1a(EUCOMM)Wtsi/Cisd2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cisd2tm1a(EUCOMM)Wtsi/H

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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