ENSMUSG00000028194


Mus musculus

Features
Gene ID: ENSMUSG00000028194
  
Biological name :Ddah1
  
Synonyms : Ddah1 / N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 / Q9CWS0
  
Possible biological names infered from orthology : dimethylarginine dimethylaminohydrolase 1 / O94760
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H2
Gene start: 145758675
Gene end: 145894277
  
Corresponding Affymetrix probe sets: 10496727 (MoGene1.0st)   1429298_at (Mouse Genome 430 2.0 Array)   1429299_at (Mouse Genome 430 2.0 Array)   1434519_at (Mouse Genome 430 2.0 Array)   1454995_at (Mouse Genome 430 2.0 Array)   1455400_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029845
Ensembl peptide - ENSMUSP00000112747
NCBI entrez gene - 69219     See in Manteia.
MGI - MGI:1916469
RefSeq - XM_017319712
RefSeq - NM_026993
RefSeq - XM_011240221
RefSeq Peptide - NP_081269
swissprot - Q9CWS0
swissprot - D3YU15
Ensembl - ENSMUSG00000028194
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01080918.1ENSDARG00000103042Danio rerio
 DDAH1ENSGALG00000008663Gallus gallus
 DDAH1ENSG00000153904Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddah2 / Q99LD8 / N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 / O95865* / dimethylarginine dimethylaminohydrolase 2*ENSMUSG0000000703948


Protein motifs (from Interpro)
Interpro ID Name
 IPR033197  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
 IPR033199  Dimethylarginine dimethylaminohydrolase/arginine deiminase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000052 citrulline metabolic process IEA
 biological_processGO:0003073 regulation of systemic arterial blood pressure IMP
 biological_processGO:0006525 arginine metabolic process IEA
 biological_processGO:0006527 arginine catabolic process IEA
 biological_processGO:0006809 nitric oxide biosynthetic process ISO
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0017014 protein nitrosylation ISO
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:1900038 negative regulation of cellular response to hypoxia IEA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016403 dimethylargininase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
eNOS activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ddah1tm1.1Yjch/Ddah1tm1.1Yjch
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0003820 increased left ventricle systolic pressure "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ddah1tm1.1Yjch/Ddah1tm1.1Yjch
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004878 increased systemic vascular resistance "increase in the normal force opposing blood flow in the peripheral blood vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ddah1tm1.1Yjch/Ddah1tm1.1Yjch
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ddah1tm1.1Yjch/Ddah1tm1.1Yjch
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ddah1tm1.1Yjch/Ddah1tm1.1Yjch
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ddah1tm1.1Geno/Ddah1tm1.1Geno
Genetic Background: Not Specified

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddah1tm1Yjch/Ddah1tm1Yjch,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Iduatm1.1Kmke/Iduatm1.1Kmke
Genetic Background: B6.129-Iduatm1.1Kmke

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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