ENSG00000153904


Homo sapiens

Features
Gene ID: ENSG00000153904
  
Biological name :DDAH1
  
Synonyms : DDAH1 / dimethylarginine dimethylaminohydrolase 1 / O94760
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p22.3
Gene start: 85318481
Gene end: 85578363
  
Corresponding Affymetrix probe sets: 1553565_s_at (Human Genome U133 Plus 2.0 Array)   209094_at (Human Genome U133 Plus 2.0 Array)   229456_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000439045
Ensembl peptide - ENSP00000488725
Ensembl peptide - ENSP00000284031
Ensembl peptide - ENSP00000411189
NCBI entrez gene - 23576     See in Manteia.
OMIM - 604743
RefSeq - XM_017000890
RefSeq - NM_001330655
RefSeq - NM_012137
RefSeq - XM_005270707
RefSeq - XM_005270710
RefSeq - XM_011541158
RefSeq - XM_017000889
RefSeq - NM_001134445
RefSeq Peptide - NP_036269
RefSeq Peptide - NP_001127917
RefSeq Peptide - NP_001317584
swissprot - B4DYP1
swissprot - O94760
swissprot - B1AKK2
Ensembl - ENSG00000153904
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01080918.1ENSDARG00000103042Danio rerio
 DDAH1ENSGALG00000008663Gallus gallus
 Ddah1ENSMUSG00000028194Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDAH2 / O95865 / dimethylarginine dimethylaminohydrolase 2ENSG0000021372249


Protein motifs (from Interpro)
Interpro ID Name
 IPR033197  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
 IPR033199  Dimethylarginine dimethylaminohydrolase/arginine deiminase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000052 citrulline metabolic process IDA
 biological_processGO:0003073 regulation of systemic arterial blood pressure ISS
 biological_processGO:0006525 arginine metabolic process IEA
 biological_processGO:0006527 arginine catabolic process TAS
 biological_processGO:0007263 nitric oxide mediated signal transduction TAS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0043116 negative regulation of vascular permeability IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity TAS
 biological_processGO:1900038 negative regulation of cellular response to hypoxia IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity TAS
 molecular_functionGO:0016403 dimethylargininase activity TAS
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
eNOS activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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