ENSMUSG00000028354


Mus musculus

Features
Gene ID: ENSMUSG00000028354
  
Biological name :Fmn2
  
Synonyms : Fmn2 / Formin-2 / Q9JL04
  
Possible biological names infered from orthology : Q9NZ56
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 174501825
Gene end: 174822729
  
Corresponding Affymetrix probe sets: 10351971 (MoGene1.0st)   1431725_at (Mouse Genome 430 2.0 Array)   1450063_at (Mouse Genome 430 2.0 Array)   1450064_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142288
Ensembl peptide - ENSMUSP00000030039
NCBI entrez gene - 54418     See in Manteia.
MGI - MGI:1859252
RefSeq - NM_019445
RefSeq Peptide - NP_062318
swissprot - A0A0A6YY57
swissprot - Q9JL04
Ensembl - ENSMUSG00000028354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fmn2aENSDARG00000023318Danio rerio
 fmn2bENSDARG00000061778Danio rerio
 FMN2ENSGALG00000031427Gallus gallus
 FMN2ENSG00000155816Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fmn1 / Q05860 / Formin-1 / Q68DA7*ENSMUSG0000004404227
Fhod3 / Q76LL6 / FH1/FH2 domain-containing protein 3 / Q2V2M9* / formin homology 2 domain containing 3*ENSMUSG0000003429515
Fhod1 / Q6P9Q4 / FH1/FH2 domain-containing protein 1 / Q9Y613* / formin homology 2 domain containing 1*ENSMUSG0000001477812
Q0QWG9 / Grid2ip / Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 (Grid2ip), transcript variant 3, mRNA. / A4D2P6* / Grid2 interacting protein*ENSMUSG0000001082512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001265  Formin homology family, Cappuccino subfamily
 IPR009408  Formin Homology 1
 IPR015425  Formin, FH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0016344 meiotic chromosome movement towards spindle pole IMP
 biological_processGO:0040038 polar body extrusion after meiotic divisions IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045010 actin nucleation IEA
 biological_processGO:0046907 intracellular transport IMP
 biological_processGO:0048477 oogenesis IMP
 biological_processGO:0051017 actin filament bundle assembly IMP
 biological_processGO:0051295 establishment of meiotic spindle localization IMP
 biological_processGO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation IMP
 biological_processGO:0070649 formin-nucleated actin cable assembly IMP
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0012737 abnormal primary polar body morphology "any structural anomaly of the small cell formed by the first meiotic division of oocytes" [MGI:anna]
Show

Allelic Composition: Ube2btm1Jhjh/Ube2btm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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