ENSMUSG00000034295


Mus musculus

Features
Gene ID: ENSMUSG00000034295
  
Biological name :Fhod3
  
Synonyms : FH1/FH2 domain-containing protein 3 / Fhod3 / Q76LL6
  
Possible biological names infered from orthology : formin homology 2 domain containing 3 / Q2V2M9
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 24709445
Gene end: 25133500
  
Corresponding Affymetrix probe sets: 10454369 (MoGene1.0st)   1435551_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041361
NCBI entrez gene - 225288     See in Manteia.
MGI - MGI:1925847
RefSeq - NM_175276
RefSeq - XM_006525830
RefSeq - NM_001289654
RefSeq - NM_001289655
RefSeq - XM_006525826
RefSeq - XM_006525828
RefSeq Peptide - NP_001276583
RefSeq Peptide - NP_001276584
RefSeq Peptide - NP_780485
swissprot - Q76LL6
Ensembl - ENSMUSG00000034295
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fhod3aENSDARG00000063682Danio rerio
 fhod3bENSDARG00000061904Danio rerio
 FHOD3ENSGALG00000013124Gallus gallus
 FHOD3ENSG00000134775Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fhod1 / Q6P9Q4 / FH1/FH2 domain-containing protein 1 / Q9Y613* / formin homology 2 domain containing 1*ENSMUSG0000001477837
Fmn2 / Q9JL04 / Formin-2 / Q9NZ56*ENSMUSG0000002835415
Fmn1 / Q05860 / Formin-1 / Q68DA7*ENSMUSG0000004404214
Q0QWG9 / Grid2ip / Mus musculus glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 (Grid2ip), transcript variant 3, mRNA. / A4D2P6* / Grid2 interacting protein*ENSMUSG0000001082513


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR014767  Diaphanous autoregulatory (DAD) domain
 IPR014768  Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
 IPR015425  Formin, FH2 domain
 IPR016024  Armadillo-type fold
 IPR027651  FH1/FH2 domain-containing protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IDA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0051639 actin filament network formation IDA
 biological_processGO:0055003 cardiac myofibril assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005865 striated muscle thin filament IEA
 cellular_componentGO:0030017 sarcomere IDA
 cellular_componentGO:0030018 Z disc IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0004085 abnormal heartbeat "anomaly in the appearance of regularly spaced contractions of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0009328 delayed heart looping "late onset of the initiation and/or completion of cardiac looping" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tenm4Tg(Col2a1-Hspg2)2Yoya/Tenm4Tg(Col2a1-Hspg2)2Yoya
Genetic Background: C57BL/6-Tenm4Tg(Col2a1-Hspg2)2Yoya

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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