ENSMUSG00000028420


Mus musculus

Features
Gene ID: ENSMUSG00000028420
  
Biological name :Tmem38b
  
Synonyms : Q9DAV9 / Tmem38b / Trimeric intracellular cation channel type B
  
Possible biological names infered from orthology : Q9NVV0 / transmembrane protein 38B
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B2
Gene start: 53826045
Gene end: 53862019
  
Corresponding Affymetrix probe sets: 10505064 (MoGene1.0st)   10505071 (MoGene1.0st)   1419949_at (Mouse Genome 430 2.0 Array)   1424700_at (Mouse Genome 430 2.0 Array)   1449677_s_at (Mouse Genome 430 2.0 Array)   1456544_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030127
Ensembl peptide - ENSMUSP00000120304
NCBI entrez gene - 52076     See in Manteia.
MGI - MGI:1098718
RefSeq - XM_006538083
RefSeq - NM_028053
RefSeq Peptide - NP_082329
swissprot - Q9DAV9
swissprot - X1WI17
Ensembl - ENSMUSG00000028420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TMEM38BENSDARG00000100549Danio rerio
 TMEM38BENSGALG00000027472Gallus gallus
 Q9NVV0ENSG00000095209Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TMP8 / Tmem38a / transmembrane protein 38A / Q9H6F2*ENSMUSG0000003179139


Protein motifs (from Interpro)
Interpro ID Name
 IPR007866  TRIC channel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0015672 monovalent inorganic cation transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0015269 calcium-activated potassium channel activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001179 thicker alveolar septa 
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0004085 abnormal heartbeat "anomaly in the appearance of regularly spaced contractions of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0004781 abnormal surfactant composition "anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0010813 abnormal alveolar lamellar body morphology "any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0010889 small alveolar lamellar bodies "decreased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0010890 decreased alveolar lamellar body number "reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Mecp2tm3.1Bird/Mecp2tm3.1Bird
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pik3catm1Jdo/Pik3catm1Jdo
Genetic Background: B6.129S7(Cg)-Pik3catm1Jdo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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