ENSMUSG00000028522


Mus musculus

Features
Gene ID: ENSMUSG00000028522
  
Biological name :Mier1
  
Synonyms : Mesoderm induction early response protein 1 / Mier1 / Q5UAK0
  
Possible biological names infered from orthology : MIER1 transcriptional regulator / Q8N108
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 103114390
Gene end: 103165754
  
Corresponding Affymetrix probe sets: 10506397 (MoGene1.0st)   1433755_at (Mouse Genome 430 2.0 Array)   1443879_at (Mouse Genome 430 2.0 Array)   1453760_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121587
Ensembl peptide - ENSMUSP00000102471
Ensembl peptide - ENSMUSP00000123637
Ensembl peptide - ENSMUSP00000030247
Ensembl peptide - ENSMUSP00000095558
Ensembl peptide - ENSMUSP00000102468
Ensembl peptide - ENSMUSP00000102470
NCBI entrez gene - 71148     See in Manteia.
MGI - MGI:1918398
RefSeq - XM_017320386
RefSeq - NM_001039081
RefSeq - NM_001286221
RefSeq - NM_001286222
RefSeq - NM_001286223
RefSeq - NM_027696
RefSeq - XM_006503398
RefSeq - XM_006503399
RefSeq - XM_006503401
RefSeq - XM_006503402
RefSeq Peptide - NP_001273152
RefSeq Peptide - NP_001034170
RefSeq Peptide - NP_001273150
RefSeq Peptide - NP_001273151
RefSeq Peptide - NP_081972
swissprot - Q5UAK0
swissprot - Q32P49
swissprot - B1AY31
swissprot - B1AY30
Ensembl - ENSMUSG00000028522
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mier1bENSDARG00000001447Danio rerio
 MIER1ENSGALG00000011118Gallus gallus
 MIER1ENSG00000198160Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mier3 / Q3UHF3 / Mesoderm induction early response protein 3 / Q7Z3K6* / MIER family member 3*ENSMUSG0000003272739
Mier2 / Q3U3N0 / Mesoderm induction early response protein 2 / Q8N344* / MIER family member 2*ENSMUSG0000004257032


Protein motifs (from Interpro)
Interpro ID Name
 IPR000949  ELM2 domain
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain
 IPR031169  Mesoderm induction early response protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016575 histone deacetylation ISO
 biological_processGO:0031937 positive regulation of chromatin silencing ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004407 histone deacetylase activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0042826 histone deacetylase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcph1tm1a(EUCOMM)Wtsi/Mcph1tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Mcph1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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