ENSMUSG00000028618


Mus musculus

Features
Gene ID: ENSMUSG00000028618
  
Biological name :Tmem59
  
Synonyms : Q9QY73 / Tmem59 / Transmembrane protein 59
  
Possible biological names infered from orthology : Q9BXS4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 107178399
Gene end: 107200996
  
Corresponding Affymetrix probe sets: 10506643 (MoGene1.0st)   1432150_at (Mouse Genome 430 2.0 Array)   1450046_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030361
Ensembl peptide - ENSMUSP00000120288
Ensembl peptide - ENSMUSP00000119701
Ensembl peptide - ENSMUSP00000102364
NCBI entrez gene - 56374     See in Manteia.
MGI - MGI:1929278
RefSeq - NM_029565
RefSeq Peptide - NP_083841
swissprot - D3Z0H8
swissprot - D3YVM2
swissprot - D6RI96
swissprot - Q9QY73
Ensembl - ENSMUSG00000028618
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem59ENSDARG00000019033Danio rerio
 TMEM59ENSGALG00000010746Gallus gallus
 Q9BXS4ENSG00000116209Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7TNI2 / Tmem59l / Transmembrane protein 59-like / Q9UK28*ENSMUSG0000003596432


Protein motifs (from Interpro)
Interpro ID Name
 IPR022065  Uncharacterised protein family, TMEM59


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010955 negative regulation of protein processing IEA
 biological_processGO:0090285 negative regulation of protein glycosylation in Golgi IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0000137 Golgi cis cisterna IEA
 cellular_componentGO:0000138 Golgi trans cisterna IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005797 Golgi medial cisterna IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 molecular_functionGO:0004175 endopeptidase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmem59tm1.1Tqw/Tmem59tm1.1Tqw,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0020340 abnormal inhibitory learning "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, ORCID: orcid.org/0000-0003-4606-0597, PMID:19321764]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0020508 decreased dendritic spine density "decrease in the number of dendritic spines in a given cross-sectional area of a dendrite" [MGI:smb]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Tmem59tm1.1Tqw/Tmem59tm1.1Tqw,Tg(Thy1-EGFP)MJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0020551 abnormal postsynaptic density morphology "any structural anomaly of the electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse" [GO:0014069]
Show

Allelic Composition: Lyz2tm1(cre)Ifo/Lyz2+,Pdcd10tm1Wami/Pdcd10tm1Wami
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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