ENSMUSG00000028655


Mus musculus

Features
Gene ID: ENSMUSG00000028655
  
Biological name :Mfsd2a
  
Synonyms : Mfsd2a / Q9DA75 / Sodium-dependent lysophosphatidylcholine symporter 1
  
Possible biological names infered from orthology : major facilitator superfamily domain containing 2A / Q8NA29
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 122946850
Gene end: 122961188
  
Corresponding Affymetrix probe sets: 10516064 (MoGene1.0st)   1428223_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116782
Ensembl peptide - ENSMUSP00000030408
NCBI entrez gene - 76574     See in Manteia.
MGI - MGI:1923824
RefSeq - NM_029662
RefSeq - XM_006503477
RefSeq Peptide - NP_083938
swissprot - B1ARS3
swissprot - Q9DA75
Ensembl - ENSMUSG00000028655
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mfsd2aaENSDARG00000030630Danio rerio
 Q6DEJ6ENSDARG00000035909Danio rerio
 MFSD2AENSGALG00000003879Gallus gallus
 MFSD2AENSG00000168389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mfsd2b / Q3T9M1 / Major facilitator superfamily domain-containing protein 2B / A6NFX1* / major facilitator superfamily domain containing 2B*ENSMUSG0000003733639


Protein motifs (from Interpro)
Interpro ID Name
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0015908 fatty acid transport IMP
 biological_processGO:0021766 hippocampus development IDA
 biological_processGO:0045056 transcytosis IMP
 biological_processGO:0051977 lysophospholipid transport IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060856 establishment of blood-brain barrier IMP
 biological_processGO:1990379 lipid transport across blood brain barrier IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005548 phospholipid transporter activity IDA
 molecular_functionGO:0015245 fatty acid transmembrane transporter activity IDA
 molecular_functionGO:0015293 symporter activity IMP
 molecular_functionGO:0051978 lysophospholipid transporter activity IDA


Pathways (from Reactome)
Pathway description
Synthesis of PC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Mfsd2atm1c(KOMP)Wtsi/Mfsd2atm1c(KOMP)Wtsi,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc1rtm1.1(KOMP)Vlcg/Mc1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mc1rtm1.1(KOMP)Vlcg/Ucd

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005283 increased unsaturated fatty acid level "greater than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005285 decreased unsaturated fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons in which the carbon chain has one or more double or triple carbon-carbon bonds " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008516 disorganized retinal outer nuclear layer "derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
Show

Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009392 retinal gliosis "increased proliferation of neuroglia in a damaged area of the retina that may lead to the formation of scar tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0010762 abnormal microglial cell activation "any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr